| vha-13 RNAi | Knockdown of vha-13 via RNAi started after the animal reached the late L4 stage does not significantly alter the lifespan [22103665]. | Worm | — | — | — |
| vab-1 RNAi | vab-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| unc-52 RNAi | RNAi knockdown of unc-52 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan [22810224]. | Worm | — | — | — |
| ucr-1 RNAi | RNAi against ucr-1 increases mean lifespan by 20% [17608836]. ucr-1 RNAi started after the animal reached the late L4 stage increase mean lifespan by 8-14% [22103665]. | Worm | +8 to +20 | — | — |
| ubh-4 RNAi | RNAi of ubh-4 starting at L1 extends mean, 25%ile and median lifespan by 3, 8 and 8% [15998808]. | Worm | +3 | +8 | — |
| ubc-18 RNAi | Loss of ubc-18 function by RNAi reduces lifespan at 25 degree Celsius, but only slightly at 20 degree Celsius. RNAi depletion of ubc-18 completely suppresses increased longevity of eat-2 mutants. RNAi depletion of ubc-18 has no effect on long lifespan of isp-1 or daf-2 mutants. Combined knockdown of wwp-1 and ubc-18 by RNAi does not shorten lifespan any further than RNAi of either single gene. Knockdown of ubc-18 suppresses extended lifespan of wwp-1 overexpression [19553937]. | Worm | — | — | — |
| ttr-5 RNAi | RNA interference of ttr-5 increase mean lifespan 14% [17608836]. | Worm | +14 | — | — |
| ttr-2 RNAi | Knockdown of ttr-2 via RNAi started after the animal reached the late L4 stage has no significant effect on mean lifespan [22103665]. | Worm | — | — | — |
| ttr-15 RNAi | RNAi against ttr-15 started after the animal reaches the late L4 stage increases lifespan by 5-8% [22103665]. | Worm | +5 to +8 | — | — |
| ttl-9 RNAi | Knockdown of ttl-9 throughout the entire life increases the lifespan by 3% [23698443]. | Worm | +3 | — | — |
| trs-1 RNAi | Knockdown of trs-1 via RNAi started after the animal reached the late L4 stage has no significant effect on the mean lifespan [22103665]. | Worm | — | — | — |
| trim-9 RNAi | RNA interference of trim-9 extends lifespan [15998808]. | Worm | — | — | — |
| trap-4 RNAi | trap-4 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| Transient CDC7 inactivation | Transient inactivation of CDC7 results in a shortened replicative lifespan [2698814]. | Yeast | — | — | — |
| tps-2 RNAi | RNA interference mediated inactivation of the trehalose-biosynthetic gene trehalose-6-phosphate synthase-2 (tps-2) decreases daf-2 mutant's long lifespan [20477758]. | Worm | — | — | — |
| tps-1 RNAi | RNA interference mediated inactivation of the trehalose-biosynthetic gene trehalose-6-phosphate synthase-1 (tps-1) decreases daf-2 mutant's long lifespan [20477758]. | Worm | — | — | — |
| tkt-1 RNAi | RNA interference of tkt-1 increases mean lifespan by 25% [17608836]. | Worm | +25 | — | — |
| tdp-1 RNAi | RNAi against tdp-1 reduces lifepsna of daf-2(e1370) mutants [Vaccaro et al. 2012]. | Worm | — | — | — |
| tct-1 RNAi | Knockdown of tct-1 via RNAi started after the animal reached the late L4 stage has not significant effect on mean lifespan [22103665]. | Worm | — | — | — |
| tbp-1 RNAi | RNAi against tbp-1 decreases mean and maximum lifespan by 15-27% and 21%, respectively [18059442]. | Worm | -15-27 | — | -21 |
| tbh-1 RNAi | Knockdown of tbh-1 via RNAi started after the animal reached the late L4 stage does not significantly affect the lifespan [22103665]. | Worm | — | — | — |
| tbc-7 RNAi | RNA interference of tbc-7 decreased median lifespan by 28% in daf-2 mutants [18006689]. | Worm | — | -28 | — |
| tbb-2 RNAi | Knockdown of tbb-2 via RNAi started after the animal reached the late L4 stage increases mean lifespan by 5-30% [22103665]. | Worm | +5 to +30 | — | — |
| tba-5 RNAi | tba-5 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| tax-6 RNAi | Post-developmental RNA interference of tax-6 increases mean lifespan by 27% [17673661]. tax-6 RNAi extends lifespan [21331044]. | Worm | +27 | — | — |
GenAge
GenDR
