| zyg-11 RNAi | zyg-11 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| Zw overexpression | Mean lifespan of G6PD overexpressor flies is extended in comparison with driver and responder controls, armadillo-GAL4 (up to 38%), Tubulin-GAL4 (up to 29%), C23-GAL4 (up to 27%), da-GAL4 (up to 24%), D42-GAL4 (up to 18%) and Appl-GAL4 (up to 16%). The maximum lifespan is also increased [18809674].
G6PD enzymatic activity as well as levels of NADPH, NADH, and the GSH/GSSG ration are increased [18809674]. | Fly | +16 to + 38 | — | — |
| ztf-12 RNAi | RNA interference of ztf-12 results in a shortened lifespan. ztf-12 is a target of daf-16 [16380712]. | Worm | — | — | — |
| ZTA1 deletion | Deletion of ZTA1 increases replicative lifespan by 15% in the alpha strain and decreased by 10% in the a strain [18340043]. Although ZTA1 was identified as a potential long-lived mutant strain in a bar-code screen, deletion of ZTA1 does not significantly affect chronological lifespan under starvation/extreme DR [20657825]. | Yeast | — | — | — |
| ZK669.4 RNAi | Knockdown of ZK669.4 via RNAi started after the animal reached the late L4 stage has no significant effect on mean lifespan [22103665]. | Worm | — | — | — |
| ZK632.4 RNAi | RNAi against ZK632.4 started after the animal reaches the late L4 stage does not significantly affect lifespan in a consistent manner [22103665]. | Worm | — | — | — |
| ZK1320.9 RNAi | Knockdown of ZK1320.9 via RNAi started after the animal reached the late L4 stage increases mean lifespan significantly by 6% and non-significantly by 4% [22103665]. | Worm | — | — | — |
| ZDS2 deletion | Deletion of ZDS2 decreases replicative lifespan by about 20% [10662670].
ZDS2 null mutation decreases rDNA silencing five-fold, increases silencing at a mutnat HMR that lacks the Rap1-binding site i the HNR-E silencer three-fold, and has no effect on telomeric silencing. ZDS2 deletion decreases rDNA silencing, increases rDNA recombination, and increases level of phosphorylated Sir3 [10662670].
| Yeast | -20 | — | — |
| ZDS1 deletion | Deletion of ZDS1 increases replicative lifespan by 37% in a SIR3-dependent manner [10662670].
Null mutation in ZDS1 causes 100-fold decrease in telomeric silencing, a nine-fold increase in rDNA silencing, reduces rDNA recombination, and decreases Sir3 phosphorylation [10662670]. | Yeast | +37 | — | — |
| ZDS1 deletion | Deletion of ZDS1 increases replcicative lifespan by 37% in a SIR3-dependent manner (in W303) [10662670].
Null mutation in ZDS1 causes 100-fold decrease in telomeric silencing, a nine-fold increase in rDNA silencing, reduces rDNA recombination, and decreases Sir3 phosphorylation [10662670]. | Yeast | +37 | — | — |
| ZC395.10 RNAi | ZC395.10 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| YVH1 deletion | Deletion of YVH1 increases replicative lifespan by 50% in the alpha strain [18340043]. | Yeast | +50 | — | — |
| YUH1 deletion | Deletion of YUH1 decreases replicative lifespan decreased 30% in the alpha strain [18340043]. | — | -30 | — | — |
| YSC84 deletion | Deletion of YSC84 increases replicative lifespan by 20% in the alpha strain [19030232]. YSC84 deletion increases replicative lifespan by 25% in the alpha strain [18340043]. | Yeast | +20 to +25 | — | — |
| YPT7 deletion | YPT7 deletion decreases replicative lifespan by 15% in the alpha strain [18340043]. Deletion of YPT7 cancels out replicative lifespan extension of 0.5% glucose restriction and results under DR also into a shorter replicative lifespan than under AL [18690010]. | Yeast | -15 | — | — |
| YPT6 deletion | Deletion of YPT6 increases replicative lifespan by 20% [19030232]. YPT6 deletion increases replicative lifespan by 30% in the alpha strain and by 10% in the a strain [18340043]. | Yeast | +10 to +30 | — | — |
| YPR011V deletion | Deletion of YPR011V decreases replicative lifespan by 20% in the a strain [18340043]. | Yeast | -20 | — | — |
| YPK1 deletion | Deletion of YPK1 decreases replicative lifespan by 20% in the alpha strain [18340043]. | Yeast | -20 | — | — |
| YPC1 deletion | Deletion of YPC1 decreases replicative lifespan by 15% in the alpha strain [19030232]. | Yeast | -15 | — | — |
| YOS9 deletion | Deletion of YOS9 decreases replicative lifespan by 10% in the alpha strain [19030232]. | Yeast | -10 | — | — |
| YOL092W deletion | Deletion of YOL092W decreases mean and maximum replicative lifespan by 36 and 21%, respectively. Lifespan of YOL092Y deletion mutants is extended by 0.5% glucose restriction [22912585]. | Yeast | -36 | — | -21 |
| YNR066C deletion | Deletion of YNR066C decrease replicative lifespan by 50% in the alpha strain [19030232]. | Yeast | -50 | — | — |
| YMR166C deletion | Deletion of YMR166C decreases replicative lifespan by 20% in the alpha strain [18340043]. | Yeast | -20 | — | — |
| YMR018W deletion | Deletion of YMR018W increases replicative lifespan by 35% in the alpha strain [18340043]. | Yeast | +35 | — | — |
| YMR010W deletion | Deletion of YMR010W increases replicative lifespan by 30% in the alpha strain [18340043]. | Yeast | +30 | — | — |
GenAge
GenDR
