| YHF1 deletion | Deletion of YFH1 decreases replicative lifespan by 50% [15130665]. | Yeast | -50 | — | — |
| YHC3 deletion | YHC3 deletion decreases 10-20% shortened lifespan [16435200]. | Yeast | -10 to -20 | — | — |
| YHB1 deletion | Deleting YHB1 partially abolished DR-induced replicative lifespan extension, whereas deleting SFA1 alone had no effect. sfa1;yhb1 double mutant cancels out the ability of moderate DR to extend replicative lifespan, but not chronological lifespan. Yhb1 and Sfa1 may play redundant roles [21584246]. | Yeast | — | — | — |
| YGR071C deletion | Deletion of YGR071C decreases replicative lifespan by 60% in the alpha strain [19030232]. | Yeast | -60 | — | — |
| YGL235W deletion | YGL235W increases replicative lifespan by 20% in the alpha strain [19030232]. | Yeast | +20 | — | — |
| YER187W deletion | Deletion of YER187W increases replicative lifespan by 30% in the alpha strain [19030232]. | Yeast | +30 | — | — |
| YER186C deletion | Deletion of YER186C increases replicative lifespan by 30% in the alpha strain [19030232]. | Yeast | +30 | — | — |
| YDR307W deletion | Deletion of YDR307W increases replicative lifespan by 30% in the alpha strain [19030232]. | Yeast | +30 | — | — |
| YDR262W deletion | Deletion of YDR262W decreases replicative lifespan by 30% in the alpha strain [19030232]. | Yeast | -30 | — | — |
| YDR248C deletion | Deletion of YDR248C increases replicative lifespan by 20% in the alpha strain [19030232]. | Yeast | +20 | — | — |
| YDR132C deletion | Deletion of YDR132C decreases replicative lifespan by 35% in the alpha strain [19030232]. | Yeast | -35 | — | — |
| YDR124W deletion | Deletion of YDR124W increases replicative lifespan by 30% in the alpha and decreases lifespan by 10% in a strain [19030232]. | Yeast | -10 to +30 | — | — |
| YDL180W deletion | YDL180W deletion impairs DR-mediated replicative lifespan extension, but does not change lifespan on AL significantly [22912585]. | Yeast | +5 | — | -6 |
| YBR238C deletion | Deletion of YBR238C increases mean replicative lifespan by 25 to 34% in the alpha and a strains [16293764; 19030232]. | Yeast | +25 to +34 | — | — |
| YBR225W deletion | Deletion of YBR225W decreases replicative lifespan by 40% in the alpha strain [19030232]. | Yeast | -40 | — | — |
| wwp-1 RNAi | RNA interference of wwp-1 decreases median lifespan by 9% in wild-type animals and 24% in daf-2 mutants [18006689]. Loss of wwp-1 function by RNAi reduces lifespan at 25 degree Celsius, but not 20 degree Celsius. Reduced levels of wwp-1 completely suppress the extended longevity of eat-2 mutants. wwp-1 RNAi does not suppress the extended lifespan of isp-1 mutants and has only minor suppressive effects on lifespan of another mitochondrial mutant, clk-1, and in cyc-1 RNAi treated worms. RNAi depletion of wwp-1 has no effect on long lifespan of daf-2 mutants [19553937].
| Worm | — | -9 | — |
| wwp-1 mutation | Loss of wwp-1 function by mutation reduces lifespan at 25 degree Celsius, but not 20 degree Celsius. Lifespan of wwp-1 mutants across entire food concentration range by bacterial dilution in liquid culture or on solid plates does not noticeable change. Reduced levels of wwp-1 completely suppress the extended longevity of eat-2 mutants [19553937].
| Worm | — | -9 | — |
| WSC4 deletion | Deletion of WSC4 decreases replicative lifespan by 30% in the alpha strain [18340043]. | Yeast | -30 | — | — |
| WRKY6 deletion | Deletion of the WRKY6 promoter results in defects in root and leaf cell senescence [11722756]. | — | — | — | — |
| Whole-body Sirt1 deletion in the adulthood | Whole-body deletion of Sirt1 in the adulthood results in mice which are seemingly normal in every way. When mice were given low doses of resveratrol after Sirt1 was disabled, there were no discernible improvement in mitochondrial function or any paramenter, while mice with normal Sirt1 function given reservatrol showed dramatic increases in energy, mitochondrial biogenesis and function, AMPK activation and increased NAD+ levels in skeletal muscle. When mice lacking Sirt1 were given low doses of reserveratrol, AMPK was unaffected. When doses were significantly increased in these mice, AMPK was activated in a SIRT1-indepent manner, but still no benefit to mitochondrial function resulted [22560220]. | Mouse | — | — | — |
| VPS8 deletion | Lack of VPS8 reduces lifespan under starvation conditions to a level similiar to that of wild-type cells incubated in synthetic complete medium and therefore blocked the lifespan-extending effect of DR [20657825]. | Yeast | — | — | — |
| VPS36 deletion | VPS36 deletion mutant had a chronological lifespan as long as wild type BY4741. Thus, Vps36 is not necessary for the starvation/extreme DR-dependent lifespan extension [20657825]. | Yeast | — | — | — |
| VPS30 deletion | VPS30 deletion prevents chronological lifespan extension induced by amino-acid DR [20421943]. | Yeast | — | — | — |
| VPS27 deletion | Under starvation conditions VPS27 deletion mutants have a dramatically reduced lifespan [20953148]. | Yeast | — | — | — |
| VPS21 deletion | Lack of VPS21 reduces lifespan under starvation conditions to a level similiar to that of wild-type cells incubated in synthetic complete medium and therefore blocked the lifespan-extending effect of DR [20657825]. | Yeast | — | — | — |
GenAge
GenDR
