| mir-239 mutation | Mutating mir-239 increases mean and maximum lifespan by 12 and 36%, respectively. Lifespan extension by mir-239 loss-of-function requires daf-16 [21129974]. | Worm | +11.8 | — | +36.0 |
| mir-246 mutation | Mutating mir-246 decreases mean and maximum lifespan by 12% [21129974]. | Worm | -11.7 | — | -12.0 |
| mir-238 mutation | Mutating mir-238 decreases mean and maximum lifespan by 18 and 24% [21129974]. mir-238(n4112) mutation decreases mean lifespan by 20% [22482727]. | Worm | -17.6 to -20 | — | -24 |
| lin-4 mutation | Loss-of-function mutation in lin-4 shortens lifespan and accelerated tissue ageing [16373574]. | Worm | — | — | — |
| Dcr-2 mutation | Median lifespan of homozyogous and transheterozyogous Dcr-2 mutants is reduced by 18-36% in males and by 27-36% in females. Dcr-2 loss changes the expression of mostly metabolic genes implicated in stress resistance and aging. Dcr-2 mutants are hypersensitive to oxidative, endoplasmic reticulum, starvation and cold stress as well as abnormal lipid and carbohydrate metabolism [21889502].
| Fly | -18 to -36 | — | — |
| SdhB mutation | SdhB mutants are hypersensitive to oxygen and displays signs of premature aging, including a 66% decrease in mean lifespan and a 17% decrease in maximum lifespan [17056719]. | Fly | -66 | — | -17 |
| Ctf1 knockout | Absence of Ctf1 is associated with decreased arterial fibrosis, stiffness mad senescence and increased longevity. Ctf1-null mice have a decrease in arterial stiffness and decrease in levels of inflammatory, apoptotic and senescence, whereas telomere-linked and DNA repair proteins as well as antioxidant enzyme activities are increased. The median lifespan of Ctf1-null mice is increased by 5 month (18%) [23172930].
Wild-type and Ctf1-null mice exhibit an increase of senescence markers (p53, Mdm2, p21, and p16) with age but are lower in Ctf1-null mice. Ctf1-null mice have a diminished vascular NFκB signaling, lower inflammation and oxidative stress and reduced senescence. Ctf1-null mice have a 12% increase in body weight, 130% increased adiponectin levels and 51% decreased leptin concentrations [23172930]. | Mouse | — | +18 | — |
| AVT1 deletion | Deletion of AVT1 accelerates the development of age-induced mitochondrial dysfunction without effecting the kinetics of vacuolar acidity decline and prevents the suppression of mitochondrial dysfunction by VMA1 and VPH2 overexpression without affecting vacuolar acidity. AVT1 deletion decreases mean, median and maximum lifespan by 21, 22, and 12%, respectively [23172144]. | Yeast | -20.6 | -22.4 | -11.8 |
| VMA2 deletion | VMA2 deletion mutants have a reduced ΔΨ and mitochondrial morphology similar to aged cells. The restoration of the vacuolar acidity in daughter cells requires V-ATPase activity as it is eliminated in VMA2 deletion mutant cells [23172144]. VMA2 deletion mutation decreases the mean replicative lifespan by 80% in the alpha strain [18340043]. Deletion of VMA2 decreases mean, median and maximum replicative lifespan by 84%, 84% and 70%, respectively. DR (0.5% glucose restriction) does not extend the replicative lifespan of VMA2 and shortens it even more [23172144]. | Yeast | -80 to -83.9 | -84.1 | -70.0 |
| HAC1 deletion | Deletion of HAC1 decreases mean, median and maximum replicative lifespan by 10, 8 and 5%, respectively [23167605]. | Yeast | +10.3 | +8.3 | +5.3 |
| lin-14 gain-of-function mutation | A gain-of-function mutation in lin-14 decreases lifespan [16373574]. | Worm | — | — | — |
| lin-14 loss-of-function mutation | A loss-of-function mutation in lin-14 extends lifespan by 31% [16373574]. lin-14(n719) mutation extends mean and maximum lifespan of control animals by 20 and 67%, respectively [23097426].
The life-extending effects is dependent on daf-16 and hsf-1 [16373574]. Inactivation of lin-14 does not increase the lifespan of pash-1 mutants [23097426].
| Worm | +20 to +31 | — | +67 |
| mir-71 mutation | Loss-of-function of mir-71 decreases lifespan [21129974]. mir-71 mutants have a reduced lifespan with 40% decrease in mean lifespan. Loss of mir-71 function suppresses the long lifespan of glp-1(e2141) mutants [22482727], | Worm | -40 | — | — |
| pash-1 mutation | pash-1 mutants have a decreased lifespan and display phenotypic and molecular signs of advantaged age earlier.
pash-1(mj100) temperature sensitive loss-of-function mutation decreases (at the permissive temperature) mean and maximum lifespan by 31 and 71%, respectively. At the restrictive temperature pash-1 mutants are slightly short-lived with a mean and maximum lifespan reduction by 13 and 54%. Lifespan of pash-1 mutants is reduced by a 24h upshift to 25 degree Celsius at the young adult stage with (36 and 78% reduction mean and maximum lifespan, respectively) [23097426].
The rescue of pash-1 expression all tissues restored almost normal lifespan. Rescue specifically in hypodermis, pharynx muscle, gut had no effect on lifespan. Rescue in body wall muscle marginal extended the lifespan, while rescue specifically in the neurons significantly restored mean but not maximum lifespan. Lifespan was also restored by combined rescue in hypodermis and muscle [23097426]. | Worm | -31 | — | -71 |
| pyk-1 mutation | pyk-1(ok1754) mutation extends the lifespan and this effect is non-additive with the lifespan extension mediated by DDS treatment [20974969]. | Worm | — | — | — |
| egm mutation | Mutation in egm confers resistance to oxidative stress and extends the lifespan [16434470]. | Fly | — | — | — |
| l(3)DTS3 mutation | Female, but not male, heterozygous mutants exhibit a 42% increase in mean lifespan [12610309]. | Fly | +42 | — | — |
| DJ-1alpha RNAi | RNA interference of DJ-1alpha shortens maximum lifespan by 13% and results in increased sensitivity to oxidative stress and motor impairments [17651920]. | Fly | — | — | -13 |
| rb mutation | Loss-of-function mutation reduces mean lifespan by 33 and maximum lifespan by 22% [17435236]. | Fly | -33 | — | -22 |
| lt mutation | Loss-of-function mutation reduces mean lifespan by 47% and maximum lifespan by 10% [17435236]. | Fly | -47 | — | -10 |
| car mutation | Loss-of-function mutation in car results in reduction of mean lifespan by 34 - 53% and maximum lifespan by 28 - 29% [17435236]. | Fly | -34 to -53 | — | -28 to -29 |
| hk mutation | Loss of function mutation in hk decreases mean lifespan by 58 - 60% and maximum lifespan by 15 - 47% [17435236]. | Fly | -58 to -60 | — | -15 to -47 |
| dor mutation | Loss-of-function mutation in dor reduces mean lifespan by 70 - 81% and maximum lifespan by 71 - 78% [17435236]. | Fly | -70 to -81 | — | -71 to -78 |
| OSH2 deletion | Deletion of OSH2 decreases mean chronological lifespan [20657825]. | Yeast | — | — | — |
| ry mutation | Loss-of-function mutation of ry reduces mean lifespan by 45% and maximum lifespan by 35% [17435236]. | Fly | -45 | — | -35 |
GenAge
GenDR
