• Species: + -
  • name effect species mean median maximum
    Homozygous knock-in of proof-reading deficient Polg Mice with a proof-reading-deficient version of Polg display an increased amount of mtDNA mutations (by 3 to 5-fold) and signs of premature ageing including a reduced lifespan, weight loss, reduced subcutaneous fat, alopecia, kyphosis, osteoporosis, anaemia, reduced fertility, and heart enlargement. Median lifespan of homozyous Polg mutant knock-in mice is 48 months [15164064]. Mouse
    • 1 intervention
    Interventions are an extension of GenAge and GenDR.