LA treatment

Species: Norway rat (Taxid: 10116)
Factor: alpha-LA
Manipulation: Diet Intervention, Drug treatment

LA confers a memory effect, by fixing the lifespan of previous feeding regimen. When animals are switched early in life (12 months) from DR to AL and supplemented with α-lipoic acid the DR typical lifespan extension is maintained, but switching early from AL supplemented with α-lipoic acid to DR blocks the lifespan extending effect [18486188].

LA exhibits the ability to compensate for age-related, long-term memory deficits in old rats [8309958].

  • 18486188: Dietary lipoic acid supplementation can mimic or block the effect of dietary restriction on life span.

  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Edit / Update (Admin) | Delete

    Comment on This Data Unit