AVT1 deletion

Species: Budding yeast (Taxid: 4932)
Factor: AVT1
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion

Deletion of AVT1 accelerates the development of age-induced mitochondrial dysfunction without effecting the kinetics of vacuolar acidity decline and prevents the suppression of mitochondrial dysfunction by VMA1 and VPH2 overexpression without affecting vacuolar acidity. AVT1 deletion decreases mean, median and maximum lifespan by 21, 22, and 12%, respectively [23172144].

Mean: -20.6
Median: -22.4
Maximum: -11.8

  • 23172144: An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast.

  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR
  • Comparisons:
  • avt1 vs. WT : -20.6(mean) -22.4(median) -11.8(max) 0.0045(p-value)

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