| abi-1 | ABl Interactor homolog | abi-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| ABL1 | c-abl oncogene 1, non-receptor tyrosine kinase | ABL1 was found to be associated with longevity [22445811]. | Human |
| ABP1 | Actin Binding Protein 1 | ABP1 deletion increases replicative lifespan by 30% in the alpha strain and decreases replicative lifespan by 20% in the a strain [18340043]. Deletion of ABP1 increases replicative lifespan by 20% in the alpha strain and decreases replicative lifespan by 20% in the a strain [19030232]. | Budding yeast |
| abu-11 | Activated in Blocked Unfolded protein response 11 | Overexpression of abu-11 extends mean lifespan by 9% to 28% [16256736]. | Nematode |
| AC000050.2 | — | AC000050.2 was found to be associated with longevity [22533364]. | Human |
| Acacb | acetyl-Coenzyme A carboxylase beta | Acacb-null animals (alias Acc2-/-) exhibit upon regular diet an increase triglyceride breakdown, leaner phenotype, increased insulin sensitivity and no effect on lifespan [17923673]. | House mouse |
| ACB1 | Acyl-CoA-Binding 1 | ACB1 deletion extends chronological lifespan under starvation/extreme DR. Similar heat-shock resistance and resistance to a very hight concentration of acetic acid (but not resistance to oxidative stress) was enhanced by the deletion of ACB1. Deletion of ACB1 in W303-1A and DBY746 genetic backgrounds on synthetic complete media causes severe growth defects and sightly shorter lifespan and also heat-sensitivity [20657825]. | Budding yeast |
| ACCN1 | amiloride-sensitive cation channel 1, neuronal | ACCN1 was found to be associated with longevity [22279548]. | Human |
| acdh-1 | Acyl CoA DeHydrogenase 1 | RNAi knockdown of acdh-1 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan. ACDH-1 significantly upregulated in eat-2. Increased content of ACDH-1 is, at least partially, required for lifespan-extension by DR [22810224]. | Nematode |
| acdh-12 | Acyl CoA DeHydrogenase 12 | RNA interference of acdh-12 starting at hatching or only during the adulthood significantly decreases eat-2 lifespan without affecting the lifespan of wild-type [22810224]. | Nematode |
| ACE | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | ACE was found to be associated with longevity [12954489]. | Human |
| ACE | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | ACE was not found to be associated with longevity [12634288]. | Human |
| ACE | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | The I/D polymorphism in ACE was a examined in centenarians (n = 338) and in adults aged 20-70 years. A variant of ACE which predisposes the coronary heat disease was more frequently in centenarians with a significant increase of the homozygous genotype [8136829].
I/D polymorphism was examined in 182 women and 100 men aged >84 years and in 100 boys and 100 girls younger than 17 years. The I/I polymorphism was depleted in the elderly males but not in the elderly females. Furthermore, significant differences were observed between ACE genotypes in elderly men and elderly women [9105559].
I/D polymorphism was examined in 394 French centenarians (13% men and 87% women) and controls (238) from 20 to 70 years of age (140 men and 98 women). Both the ACE D allele and ACE D/D genotype were more frequent in centenarians in comparison with controls, without sex-related differences nor significant correlation with a cardiovascular pathology [9761238].
I/D polymorphism was examined in 424 subjects comprising 227 Uighur individuals, 108 Kazakh individuals, and 89 Han individuals. All subjects in the latter two groups ranged in age from 65 to 70 years, whereas the Uighur subjects comprised two different age groups: those ranging in age from 59 to 70 years and those ranging in age from 90 to 113 years. Within the Uighur group, frequency of the D allele was significantly higher in the group aged >90 than in the group aged <70. The overall distributions of alleles in the three groups did not differ significantly [11773214].
Alleles of ACE was found to be associated with longevity [12547486; 22456784].ACE was found to be associated with longevity [11773214]. ACE was found to be associated with longevity [16960022]. ACE was found to be associated with longevity [19502260]. ACE was found to be associated with longevity [12634288]. ACE was found to be associated with longevity [23389097]. ACE was found to be associated with longevity [12547486]. ACE was found to be associated with longevity [22456784]. ACE was found to be associated with longevity [14528043]. ACE was found to be associated with longevity [8136829]. ACE was found to be associated with longevity [21614448]. ACE was found to be associated with longevity [21330423]. ACE was found to be associated with longevity [19502260]. ACE was found to be associated with longevity [9105559]. ACE was found to be associated with longevity [9761238]. ACE was not found to be associated with longevity [11280044]. ACE was not found to be associated with longevity [14528043]. ACE was not found to be associated with longevity [21330423]. ACE was not found to be associated with longevity [9761238]. ACE was found to be associated with longevity [23623925]. | Human |
| ACE1 | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | ACE1 was found to be associated with longevity [12954489]. | Human |
| ACH1 | Acetyl CoA Hydrolase 1 | ACH1 deletion cells accumulate a high amount of extracellular acetic acid and display a reduced mean and maximum chronological lifespan. Maximum lifespan is reduced by 32%. Lifespan shortening is completely abrogated by alleviating the acid stress either by a DR regimen that prevents acetic acid production or by transferring chronologically aging mutant cells to water. Deletion of ACH1 is accompanied by reactive oxygen species accumulation, severe mitochondrial damage, and an early insurgence of apoptosis [22754872]. | Budding yeast |
| acl-11 | ACyLtransferase-like 11 | RNA interference of acl-11 leads to lifespan extension [12447374]. | Nematode |
| aco-2 | ACOnitase | RNA interference of aco-2 leads to lifespan extension [15998808]. | Nematode |
| ACO1 | ACOnitase 1 | Deletion of ACO1 decreases mean chronological lifespan by 42 - 56% in diploid cells [21447998]. | Budding yeast |
| ACO2 | ACOnitase 2 | Deletion of ACO2 increases replicative lifespan by 20% in the alpha strain and decreases it by 10% in the a strain [18340043]. Its deletion increases mean chronological lifespan by 6 - 44% (6, 22, 20, 20, 19, 44) in diploid cells [21447998]. | Budding yeast |
| ACPL2 | acid phosphatase-like 2 | ACPL2 was found to be associated with longevity [22445811]. | Human |
| acs-5 | fatty Acid CoA Synthetase family 5 | RNA interference of acs-5 increases mean lifespan by 52% [17608836]. | Nematode |
| ACS2 | Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions | Replicative lifespan decreased by 70% in the alpha strain | Budding yeast |
| ACT | ACTin | An ACT1 allele which reduces actin dynamics decreases chronological lifespan, while an allele that increases actin dynamics increases chronological lifespan by 32% [15024029]. | Budding yeast |
| ACTN3 | actinin, alpha 3 | ACTN3 was not found to be associated with longevity [21407828]. | Human |
| ADA | adenosine deaminase | ADA was found to be associated with longevity [20174870]. ADA was found to be associated with longevity [21865054]. | Human |
