Angiotensin I-converting enzyme gene polymorphism in two ethnic groups living in Brazil's southern region: association with age.

Authors: Da Cruz IB; Oliveira G; Taufer M; Leal NF; Schwanke CH; Glock L; Moriguchi Y; Moriguchi EH

Abstract: BACKGROUND: Several studies have been published on the association between ACE (angiotensin I-converting enzyme) polymorphism and longevity. However, the results are controversial. METHODS: We analyzed the association between ACE polymorphism and age in two different ethnic populations: a population originating from different European countries (Gaucha Population, GP) and a population originating from Japan (JP). Both populations live in Brazil's southern region. RESULTS: We determined the ACE genotype in 834 persons aged 10-104 years. The ACE genotype and allele frequencies differed between the two populations, with the D allele being more frequent in GP than JP. We found an association between the DD genotype and D allele and age in the GP group only. The ACE polymorphism-age association occurred at age >60 years in the GP population with decreasing II frequency. CONCLUSION: We cannot dismiss the possibility of the association between ACE polymorphism and age involving linkage disequilibrium, since the nature of this phenomenon is still controversial. From our studies, it appears that there is a correlation between age, ethnicity, and ACE polymorphism. More of such studies are warranted, as further investigation in this area will have a high clinical relevance to cardiovascular disease and aging research.

Keywords: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging/*genetics; Asian Continental Ancestry Group/*genetics; Base Sequence; Brazil; Child; Cohort Studies; European Continental Ancestry Group/*genetics; Female; Gene Frequency; Genetics, Population; Humans; Logistic Models; Longevity/genetics; Male; Middle Aged; Molecular Sequence Data; Multivariate Analysis; Peptidyl-Dipeptidase A/*genetics; Polymerase Chain Reaction; *Polymorphism, Genetic; Rural Population
Journal: The journals of gerontology. Series A, Biological sciences and medical sciences
Volume: 58
Issue: 9
Pages: M851-6
Date: Oct. 7, 2003
PMID: 14528043
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Citation:

Da Cruz IB, Oliveira G, Taufer M, Leal NF, Schwanke CH, Glock L, Moriguchi Y, Moriguchi EH (2003) Angiotensin I-converting enzyme gene polymorphism in two ethnic groups living in Brazil's southern region: association with age. The journals of gerontology. Series A, Biological sciences and medical sciences 58: M851-6.


Longevity Variant Associations (p-value):
  • rs4646994 (0.003)

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