| ANS1 | — | Deletion of ANS1 decreases replicative lifespan by 25% in the alpha strain [19030232]. | Budding yeast |
| ARP1 | Actin-Related Protein 1 | Deletion of ARP1 decreases replicative lifespan by 40% in the alpha strain [18340043; 19030232]. | Budding yeast |
| ATG15 | AuTophaGy related 15 | Deletion of ATG15 does not affect the lifespan significantly on AL, while DR shortens replicative lifespan of ATG15 deletion mutant by 28% [18690010]. | Budding yeast |
| ATH1 | Acid TreHalase | Deletion of ATH1 extend the mean chronological lifespan by 17% (at 30 degree Celsus in BY4742) [22783207].
ATH1 mutants have higher trehalose levels until the end of the post-diauxic growth phase, but reaches a plateau at the level of 50-70% of wild-type in the stationary phase [22783207]. | Budding yeast |
| ATP1 | ATP synthase 1 | Deletion of ATP1 increases chronological lifespan by up to 50% [17492370], but decreases replicative lifespan by 70% in the alpha strain [18340043]. | Budding yeast |
| AVO2 | Adheres VOraciously (to TOR2) | Deletion of AVO2 extends chronological lifespan [21641548]. | Budding yeast |
| BAS1 | BASal 1 | Deletion of BAS1 increases replicative lifespan by 30% in the alpha strain [16293764; 19030232]. | Budding yeast |
| BIM1 | BInding to Microtubules 1 | Deletion of BIM1 increases mean chronological lifespan by 42 - 133% (42, 47, 49, 133) in diploid cells [21447998].
| Budding yeast |
| RPS18A | Ribosomal Protein of the Small subunit 18A | Deletion of both RPS18A and RPS18B paralogs increases replicative lifespan by moderately, but significantly by 15% [17174052]. Deletion of RPS18A alone does not effect mean replicative lifespan significantly [22377630]. | Budding yeast |
| RPS18B | Ribosomal Protein of the Small subunit 18B | Deletion of both RPS18A and RPS18B paralogs increases replicative lifespan moderately, but significantly by 15% [17174052]. | Budding yeast |
| BRE5 | BREfeldin A sensitivity 5 | Deletion of BRE5 increases mean replicative lifespan by 30% [16293764] and mean chronological lifespan in diploid cells [21447998] | Budding yeast |
| BUL1 | Binds Ubiquitin Ligase 1 | Deletion of BUL1 does non-significantly reduces mean chronological lifespan under starvation/extreme DR [20657825]. | Budding yeast |
| CAT5 | CATabolite repression 5 | Deletion of CAT5 decreases chronological lifespan by up to 50% [17492370] and also decreases replicative lifespan by 30% in the alpha strain [18340043]. | Budding yeast |
| CBP4 | Cytochrome B mRNA Processing 4 | Deletion of CBP4 increases mean chronological lifespan by 88 - 165% (88, 95, 146, 165) in diploid cells [21447998]. | Budding yeast |
| CCR4 | Carbon Catabolite Repression 4 | Deletion of CCR4 increases mean chronological lifespan by 20 - 41% (20, 33, 41) in diploid cells [21447998]. In W303R CCR4 deletion shortens replicative lifespan by approximately 80% and results in temperature sensitivity that is suppressed by SSD1-V. SSD1-V partially suppresses the short-lifespan of ccr4 mutant. CCR4 mutation is synthetically lethal in combination with deletion of MPT5 in the absence of SSD1-V [11805047]. | Budding yeast |
| CCS1 | Copper Chaperone for SOD1 1 | Deletion of CCS1 reduces replicative lifespan by 50% [17460215]. | Budding yeast |
| CIN8 | Chromosome INstability 8 | Deletion of CIN8 increases mean chronological lifespan by 8 - 74% in diploid cells [21447998]. | Budding yeast |
| CLA4 | CLn Activity dependant 4 | Deletion of CLA4 decreases replicative lifespan by 60% in the alpha strain [18340043; 19030232]. | Budding yeast |
| COQ3 | COenzyme Q 3 | Deletion of COQ3 decreases chronological lifespan and renders cells respiratory deficient and sensitive to hydrogen peroxide [12586694]. | Budding yeast |
| CPR7 | Cyclosporin-sensitive Proline Rotamase 7 | Deletion of CPR7 has no effect on lifespan replicative lifespan, but increases chronological lifespan [11361336] | Budding yeast |
| CRC1 | CaRnitine Carrier 1 | Deletion of CRC1 increases replicative lifespan [16293764]. CRC1 deletion increases replicative lifespan by 25% in the alpha strain [19030232] | Budding yeast |
| CSR2 | Chs5 Spa2 Rescue 2 | Deletion of CSR2 results in higher levels of intracellular reactive oxygen species, augmentation of scavenging enzymes and extends replicative as well as chronological lifespan [16336970]. | Budding yeast |
| CTF4 | Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion | Deletion of CTF4 results in an approximately 75% reduced mean replicative lifespan [12024027]. | Budding yeast |
| CTF8 | Chromosome Transmission Fidelity 8 | Deletion of CTF8 increases mean chronological lifespan by 15-92% (15, 18, 42, 45, 92) in diploid cells [21447998]. | Budding yeast |
| CUP9 | Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription | Deletion of CUP9 increases replicative lifespan by 30% in the alpha and a strains [18340043]. Although CPU9 was identified as a potential long-lived mutant strain in a bar-code screen, the chronological lifespan of CUP9 deletion mutant is not significantly different from than of wild-type under starvation/extreme DR [20657825]. | Budding yeast |
