| Fhos | — | Fhos exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705].
Fhos is upregulated under microbial infection [12431377] and downregulated with age [17196240]. | Fruit fly |
| CG5389 | — | RNAi of complex V subunit CG5389 results in increased mean longevity under standard laboratory food conditions (3% yeast) in males. RNAi started from the development results in a mild lifespan increase in both sexes (3-11% in females and 3-8% in males). Post-developmental RNAi and silencing limited to neurons has variable effects with reduction in lifespan of up to 9% [19747824]. Under rich media conditions CG5389 knockdown throughout development and adulthood increases mean lifespan by 26% and abolished the lifespan extension by DR (started in the adulthood) in males. Suppression of CG5389 only during the adulthood either via RNAi by tub-GS or via oligomycin (a specific inhibitor of complex V) feeding prevents an increase in longevity under DR (started in the adulthood) in males [19968629]. | Fruit fly |
| CG4726 | — | CG4726 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. | Fruit fly |
| CG6041 | — | CG6041 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. | Fruit fly |
| CG11015 | — | CG11015 is translational upregulated upon DR. Under rich nutritional conditions lifespan of CG11015 RNAi treated animals is indistinguishable from that of controls, while upon DR, lifespan extension is diminished in males and females [19804760]. | Fruit fly |
| CG6048 | — | CG6048 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. | Fruit fly |
| Thor | — | Null mutation in Thor (alias d4E-BP) causes a significant decrease in longevity (-25% median lifespan in males). Thor is strongly upregulated during starvation. foxo and Thor null mutants are compromised in stress resistant. Stress resistance of foxo null mutants is rescued by Thor overexpression [16055649]. Thor is upregulated on the protein level in a foxo-independent manner upon DR, while it is transcriptional induced in a foxo-dependent fashion by starvation. Thor null mutants cancel out DR-induced lifespan extension, because mutants exhibit a diminished change in lifespan when nutrient conditions were varied. Ubiquitously expression of Thor rescued DR response in females and males. Thor null mutants have a wild-type similar reduction in egg production upon DR. Ubiquitously overexpression of wild-type Thor causes no change under AL, but an activated allele (with more than 3-fold increased binding activity to delF4E) significantly extends lifespan of females (weak allele) and females as well as males (strong allele). Mean lifespan is extended by 11 to 40%. Median lifespan of males and females is enhanced by by 11 and 22%, respectively. Maximum lifespan is extended by 16 and 18% for males and females, respectively. Under DR (0.25% YE) there is no lifespan extension, beyond the effect of DR alone, in all (wild-type, weak and strong) Thor alleles [19804760].
Lifespan of animals with increased Pten and 4E-BP activity in muscle exhibit and extended mean and maximum lifespan by 20% and 15.8% [21111239]. | Fruit fly |
| CG12004 | — | CG12004 exhibits a coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG6511 | — | CG6511 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. | Fruit fly |
| CG13306 | — | CG13306 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. | Fruit fly |
| CG34426 | — | CG34426 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. | Fruit fly |
| CG5194 | — | CG5194 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705].
| Fruit fly |
| Doc1 | — | Doc1 exhibits a coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in the abdomen of for longevity selected lines [23106705].
| Fruit fly |
| Tequila | — | Tequila exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705].
Tequila is upregulated with age and microbial infection, while downregulated with oxidative stress [11095759; 17196240; 15475297].
| Fruit fly |
| ovo | — | The dominant ovoD1 allele extends female lifespan by approximately 50%. It does not synergize or prevent life-extension caused by chico [10617470; 11292874].
ovoD1 mutants are sterile [Mevel-Ninio et al. 1991]. | Fruit fly |
| CG12090 | — | CG12090 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| p53 | — | Overexpression of wild-type p53 during adult life has no significant effect on lifespan. Expression of dominant-negative versions of p53 in adult neurons extends lifespan by 58% in females and by 32% in males and increases resistance to genotoxic stress and resistance to oxidative stress, but not to starvation or heat stress, while not affecting egg production or physical activity.
Dominant negative p53 expression cancels out lifespan extension effect of DR, low calorie-food (5% SY). Muscle or fat body specific expression of a dominant negative form of p53 as well as globally lack of p53 decreases lifespan [16303568]. Loss of p53 activity slightly shortens the lifespan. Mutants that lack p53 survive well up to 50 days, but mortality rate increases relative to wild-type at later ages. p53 mutant animals are extremely sensitive to irradiation [12935877].
Expression of dominant-negative (DN) form of p53 in adult neurons, but not in muscle or fat body cells, extends median lifespan by 19% and maximum lifespan by 8%. The lifespan of dietary-restricted flies is not further extended by simultaneously expressing DN-DMp53 in the nervous system, indicating that a decrease in Dmp53 activity may be part of the DR lifespan-extending effect. Selective expression of DN-Dmp53 in only the 14 insulin-producing cell (IPCs) in the brain extends lifespan to the same extent as expression in all neurons and this lifespan extension is not additive with DR [17686972].
| Fruit fly |
| LY294002 | — | Treatment of Drosophila imago with 5 micromolar LY294002 increases median (by 14%) and maximum (by 16-22%) lifespan (p<0.001) in females and males, respectively [22661237].
Low dose of LY294002 (5 microM) slightly increase the median and maximum lifespan of fruit fly [20017609]. | Fruit fly |
| CG7852 | — | CG7852 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head and abdomen of animals that were selected for longevity [23106705]. | Fruit fly |
| CG13917 | — | CG13917 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG12016 | — | CG12016 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG16711 | — | CG16711 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG4942 | — | CG4942 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG32022 | — | CG32022 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG12576 | — | CG12576 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
