F42A6.1 | — | RNA interference increased mean lifespan by 22%. | Nematode |
Y71G12B.4 | — | RNA interference extends lifespan. | Nematode |
F42G10.1 | — | RNA interference extends lifespan. | Nematode |
Y71H2AR.2 | — | RNA interference extends lifespan. | Nematode |
RRG1 | — | Deletion of RRG1 decreases replicative lifespan by 50% in the alpha strain [19030232]. | Budding yeast |
F43D2.1 | — | RNA interference decreased median lifespan by 20% in wild type animals, 34% in a daf-2 background and 35% in daf-2/daf-16 double mutants. | Nematode |
Y75B8A.13 | — | RNA interference extends lifespan. | Nematode |
YDR089W | — | Deletion of YDR089W decreases replicative lifespan by 30% in the alpha strain [19030232]. | Budding yeast |
Y75B8A.33 | — | RNA interference extends lifespan. | Nematode |
YDR124W | — | Deletion of YDR124W increases replicative lifespan by 30% in the alpha and decreases lifespan by 10% in a strain [19030232]. | Budding yeast |
F43G9.1 | — | RNA interference extends lifespan. | Nematode |
Intergenic | — | Intergenic was found to be associated with longevity [21418511]. Intergenic was found to be associated with longevity [22533364]. Intergenic was found to be associated with longevity [14615589]. Intergenic was found to be associated with longevity [21782286]. Intergenic was found to be associated with longevity [22279548]. | Human |
F49C12.9 | — | RNA interference increased mean lifespan by 19%. | Nematode |
YDR132C | — | Deletion of YDR132C decreases replicative lifespan by 35% in the alpha strain [19030232]. | Budding yeast |
F49F1.12 | — | RNA interference extends lifespan. | Nematode |
YBR238C | — | Deletion of YBR238C increases mean replicative lifespan by 25 to 34% in the alpha and a strains [16293764; 19030232]. | Budding yeast |
YDR248C | — | Deletion of YDR248C increases replicative lifespan by 20% in the alpha strain [19030232]. | Budding yeast |
mir-71 | — | Loss and gain-of-function of mir-71 decreases and increases lifespan, respectively [21129974]. mir-71 mutants have a reduced lifespan with 40% decrease in mean lifespan, while extra copies of mir-71 extend the lifespan with an increase in lifespan by 15 - 25% [22482727],
Loss of mir-71 function suppresses the long lifespan of glp-1(e2141) mutants [22482727],
During adulthood mir-71 is strongly expressed in the intestine, body wall muscles and neurons. mir-71 is upregulated in aging adults [22482727], | Nematode |
F52C6.2 | — | RNA interference decreased median lifespan by 19% in wild type animals and 46% in daf-2 mutants. | Nematode |
YDR262W | — | Deletion of YDR262W decreases replicative lifespan by 30% in the alpha strain [19030232]. | Budding yeast |
age-2 | — | Homocygous age-2 mutation increases mean (+43%, +31%, +38%) and maximum (+29%, +36%, +18%)) lifespan by about 20%. age-2 mutant exhibit normal motility, slightly higher swimming rates, reduced fertility and somewhat longer development times and slightly larger size at the first egg laying. Lifespan is extended by reducing the initial mortality rate. age-2 mutation complements other aging gene mutations such as age-1, daf-2, spe-26, clk-1, clk-3 and gro-1. A age-1 age-2 double mutant lives longer than animals with individual mutations and exhibits a longer lifespan at 25 degree Celsius than at 20 degree Celsius [10219000]. | Nematode |
mir-238 | — | Mutating mir-238 decreases mean and maximum lifespan by 18 and 24% [21129974]. mir-238(n4112) mutation decreases mean lifespan by 20% [22482727]. | Nematode |
F53F4.11 | — | RNA interference in adulthood resulted in a 27% mean lifespan extension. | Nematode |
mir-246 | — | Mutating mir-246 decreases mean and maximum lifespan by 12%, while its overexpression increases mean and maximum lifespan by 6 and 5 - 14%, respectively [21129974]. | Nematode |
F55B11.1 | — | RNA interference extends lifespan. | Nematode |