Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • symbol name observation species
    F42A6.1 RNA interference increased mean lifespan by 22%. Nematode
    Y71G12B.4 RNA interference extends lifespan. Nematode
    F42G10.1 RNA interference extends lifespan. Nematode
    Y71H2AR.2 RNA interference extends lifespan. Nematode
    RRG1 Deletion of RRG1 decreases replicative lifespan by 50% in the alpha strain [19030232]. Budding yeast
    F43D2.1 RNA interference decreased median lifespan by 20% in wild type animals, 34% in a daf-2 background and 35% in daf-2/daf-16 double mutants. Nematode
    Y75B8A.13 RNA interference extends lifespan. Nematode
    YDR089W Deletion of YDR089W decreases replicative lifespan by 30% in the alpha strain [19030232]. Budding yeast
    Y75B8A.33 RNA interference extends lifespan. Nematode
    YDR124W Deletion of YDR124W increases replicative lifespan by 30% in the alpha and decreases lifespan by 10% in a strain [19030232]. Budding yeast
    F43G9.1 RNA interference extends lifespan. Nematode
    Intergenic Intergenic was found to be associated with longevity [21418511]. Intergenic was found to be associated with longevity [22533364]. Intergenic was found to be associated with longevity [14615589]. Intergenic was found to be associated with longevity [21782286]. Intergenic was found to be associated with longevity [22279548]. Human
    F49C12.9 RNA interference increased mean lifespan by 19%. Nematode
    YDR132C Deletion of YDR132C decreases replicative lifespan by 35% in the alpha strain [19030232]. Budding yeast
    F49F1.12 RNA interference extends lifespan. Nematode
    YBR238C Deletion of YBR238C increases mean replicative lifespan by 25 to 34% in the alpha and a strains [16293764; 19030232]. Budding yeast
    YDR248C Deletion of YDR248C increases replicative lifespan by 20% in the alpha strain [19030232]. Budding yeast
    mir-71 Loss and gain-of-function of mir-71 decreases and increases lifespan, respectively [21129974]. mir-71 mutants have a reduced lifespan with 40% decrease in mean lifespan, while extra copies of mir-71 extend the lifespan with an increase in lifespan by 15 - 25% [22482727], Loss of mir-71 function suppresses the long lifespan of glp-1(e2141) mutants [22482727], During adulthood mir-71 is strongly expressed in the intestine, body wall muscles and neurons. mir-71 is upregulated in aging adults [22482727], Nematode
    F52C6.2 RNA interference decreased median lifespan by 19% in wild type animals and 46% in daf-2 mutants. Nematode
    YDR262W Deletion of YDR262W decreases replicative lifespan by 30% in the alpha strain [19030232]. Budding yeast
    age-2 Homocygous age-2 mutation increases mean (+43%, +31%, +38%) and maximum (+29%, +36%, +18%)) lifespan by about 20%. age-2 mutant exhibit normal motility, slightly higher swimming rates, reduced fertility and somewhat longer development times and slightly larger size at the first egg laying. Lifespan is extended by reducing the initial mortality rate. age-2 mutation complements other aging gene mutations such as age-1, daf-2, spe-26, clk-1, clk-3 and gro-1. A age-1 age-2 double mutant lives longer than animals with individual mutations and exhibits a longer lifespan at 25 degree Celsius than at 20 degree Celsius [10219000]. Nematode
    mir-238 Mutating mir-238 decreases mean and maximum lifespan by 18 and 24% [21129974]. mir-238(n4112) mutation decreases mean lifespan by 20% [22482727]. Nematode
    F53F4.11 RNA interference in adulthood resulted in a 27% mean lifespan extension. Nematode
    mir-246 Mutating mir-246 decreases mean and maximum lifespan by 12%, while its overexpression increases mean and maximum lifespan by 6 and 5 - 14%, respectively [21129974]. Nematode
    F55B11.1 RNA interference extends lifespan. Nematode
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    • 25 of 2668 factors
    Factors are an extension of GenAge and GenDR.

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