| R08E3.3 | — | RNA interference extended lifespan. | Nematode |
| ZC250.3 | — | RNA interference decreased median lifespan by 29% in wild type animals, 41% in a daf-2 background and 25% in daf-2/daf-16 double mutants. | Nematode |
| R10H10.7 | — | RNA interference increased mean lifespan by 22%. | Nematode |
| F56D5.5 | — | RNA interference increased mean lifespan by 20%. | Nematode |
| F57B10.3 | — | RNA interference against F57B10.3 extends mean and maximum lifespan by 21% and 48%, respectively, without causing any developmental pleiotropies or defects in mitochondrial morphology. Lifespan extension by F57B10.3 is suppressed by daf-16. F57B10.3 RNAi animals have lower ATP content and oxygen consumption [12447374]. | Nematode |
| ZK1127.5 | — | RNA interference in adulthood extended mean lifespan by 24%. | Nematode |
| R12B2.6 | — | RNA interference decreased median lifespan by 22% in wild type animals and 24% in daf-2 mutants. | Nematode |
| F59A3.3 | — | RNA interference in adulthood resulted in a 14% mean lifespan extension. | Nematode |
| R53.4 | — | RNA interference in adulthood extended mean lifespan by 20%. | Nematode |
| mir-124 | — | Loss of mir-124 increases reactive oxygen species formation and accumulation of the aging marker lipofuscin, reduces whole body ATP levels and results in reduction in lifespan [23075628].
Supplementation of vitamin C normalizes the reduced median lifespan of mir-124 mutants [23075628].
The expression of the conserved mir-124 in whole wrn-1 mutants (which premature age) is significantly reduced [23075628]. | Nematode |
| F59B2.8 | — | RNA interference in adulthood shortened the extended lifespan of daf-2(mu150) mutants. Only a negligible or small reduction in the lifespan of wild-type worms was observed in knockouts. | Nematode |
| ZK686.2 | — | RNA interference in adulthood extended mean lifespan by 24%. | Nematode |
| F59B8.2 | — | RNA interference resulted in extended lifespan. | Nematode |
| ZK809.3 | — | RNA interference increased mean lifespan by 100%. | Nematode |
| F59C6.5 | — | RNA interference in adulthood extended mean lifespan by 19%. | Nematode |
| F54D5.11 | — | F54D5.11 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| Ash-2 | — | RNAi extended fertile lifespan. | Nematode |
| F54D5.11 | — | F38E11.5 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| Rbr-2 | — | RNAi decreased lifespan. | Nematode |
| cul-6 | — | RNAi decrease lifespan of daf-2 mutant and increased lifespan glp-1 mutant, but had no significant effect on lifespan of WT. | Nematode |
| rpn-1 | — | RNAi decreased lifespan of WT, daf-2 and glp-1 mutant. | Nematode |
| rpn-3 | — | RNAi decreased lifespan of WT, daf-2 and glp-1 mutant. | Nematode |
| rpn-6 | — | RNAi decreased lifespan of WT, daf-2 and glp-1 mutant. | Nematode |
| rpn-8 | — | RNAi decreased lifespan of WT, daf-2 and glp-1 mutant. | Nematode |
| rpn-9 | — | RNAi decreased lifespan of WT, daf-2 and glp-1 mutant. | Nematode |
