| F42A6.1 | — | RNA interference increased mean lifespan by 22%. | Nematode |
| Y71G12B.4 | — | RNA interference extends lifespan. | Nematode |
| F42G10.1 | — | RNA interference extends lifespan. | Nematode |
| Y71H2AR.2 | — | RNA interference extends lifespan. | Nematode |
| F43D2.1 | — | RNA interference decreased median lifespan by 20% in wild type animals, 34% in a daf-2 background and 35% in daf-2/daf-16 double mutants. | Nematode |
| Y75B8A.13 | — | RNA interference extends lifespan. | Nematode |
| Y75B8A.33 | — | RNA interference extends lifespan. | Nematode |
| F43G9.1 | — | RNA interference extends lifespan. | Nematode |
| F49C12.9 | — | RNA interference increased mean lifespan by 19%. | Nematode |
| F49F1.12 | — | RNA interference extends lifespan. | Nematode |
| mir-71 | — | Loss and gain-of-function of mir-71 decreases and increases lifespan, respectively [21129974]. mir-71 mutants have a reduced lifespan with 40% decrease in mean lifespan, while extra copies of mir-71 extend the lifespan with an increase in lifespan by 15 - 25% [22482727],
Loss of mir-71 function suppresses the long lifespan of glp-1(e2141) mutants [22482727],
During adulthood mir-71 is strongly expressed in the intestine, body wall muscles and neurons. mir-71 is upregulated in aging adults [22482727], | Nematode |
| F52C6.2 | — | RNA interference decreased median lifespan by 19% in wild type animals and 46% in daf-2 mutants. | Nematode |
| age-2 | — | Homocygous age-2 mutation increases mean (+43%, +31%, +38%) and maximum (+29%, +36%, +18%)) lifespan by about 20%. age-2 mutant exhibit normal motility, slightly higher swimming rates, reduced fertility and somewhat longer development times and slightly larger size at the first egg laying. Lifespan is extended by reducing the initial mortality rate. age-2 mutation complements other aging gene mutations such as age-1, daf-2, spe-26, clk-1, clk-3 and gro-1. A age-1 age-2 double mutant lives longer than animals with individual mutations and exhibits a longer lifespan at 25 degree Celsius than at 20 degree Celsius [10219000]. | Nematode |
| mir-238 | — | Mutating mir-238 decreases mean and maximum lifespan by 18 and 24% [21129974]. mir-238(n4112) mutation decreases mean lifespan by 20% [22482727]. | Nematode |
| F53F4.11 | — | RNA interference in adulthood resulted in a 27% mean lifespan extension. | Nematode |
| mir-246 | — | Mutating mir-246 decreases mean and maximum lifespan by 12%, while its overexpression increases mean and maximum lifespan by 6 and 5 - 14%, respectively [21129974]. | Nematode |
| F55B11.1 | — | RNA interference extends lifespan. | Nematode |
| R02D3.3 | — | R02D3.3 RNAi in the adulthood extends mean and maximum lifespan by 13 and 22%, respectively [23144747]. | Nematode |
| mir-239 | — | Mutating mir-239 increases mean and maximum lifespan by 12 and 36%, respectively, whereas overexpressing mir-239 decreases mean and maximum lifespan by 13 and 17 - 33%, respectively [21129974]. | Nematode |
| F55B11.3 | — | RNA interference extends lifespan. | Nematode |
| F55B11.5 | — | RNA interference extends lifespan. | Nematode |
| R05A10.5 | — | RNA interference extended lifespan. | Nematode |
| ZC132.3 | — | RNA interference in adulthood extended mean lifespan by 26%. | Nematode |
| mir-58 | — | mir-58(n4640) mutation decreases the mean lifespan by 20% [22482727]. | Nematode |
| F55B12.4 | — | RNA interference decreased median lifespan by 52% in wild type animals, 44% in a daf-2 background and 14% in daf-2/daf-16 double mutants. | Nematode |
