Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Species: + -
  • symbol name observation species
    ZWINT ZW10 interactor ZWINT was found to be associated with longevity [22279548]. Human
    ZNF331 zinc finger protein 331 ZNF331 was found to be associated with longevity [21782286]. Human
    ZBTB20 zinc finger and BTB domain containing 20 ZBTB20 was found to be associated with longevity [22279548]. Human
    XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) XRCC5 was found to be associated with longevity [22406557; 16518718]. Human
    XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 XRCC4 was found to be associated with longevity [16518718]. Human
    XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 XRCC3 was found to be associated with longevity [16518718]. Human
    XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 XRCC1 was found to be associated with longevity [16518718]. Human
    XKR6 XK, Kell blood group complex subunit-related family, member 6 XKR6 was found to be associated with longevity [22279548]. Human
    XDH xanthine dehydrogenase XDH was found to be associated with longevity [22406557; 22279548]. Human
    WWOX WW domain containing oxidoreductase WWOX was found to be associated with longevity [22279548]. WWOX was found to be associated with longevity [24244950]. Human
    WDR72 WD repeat domain 72 WDR72 was found to be associated with longevity [22279548]. Human
    VWA5A von Willebrand factor A domain containing 5A VWA5A was found to be associated with longevity [21782286]. Human
    VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) VPS13D was found to be associated with longevity [22279548]. Human
    Vitamin D receptor vitamin D (1,25- dihydroxyvitamin D3) receptor Vitamin D receptor was not found to be associated with longevity [21051524]. Human
    VEGFA vascular endothelial growth factor A VEGFA was found to be associated with longevity [17574707]. VEGFA was not found to be associated with longevity [17574707]. Human
    VDR vitamin D (1,25- dihydroxyvitamin D3) receptor VDR was found to be associated with longevity [21051524]. VDR was not found to be associated with longevity [20407924]. VDR was found to be associated with longevity [20407924]. Human
    VASH1 vasohibin 1 VASH1 was found to be associated with longevity [22279548]. Human
    upstream of FOXO3A upstream of FOXO3A was found to be associated with longevity [19196970]. Human
    Upstram of FOXO3A Upstram of FOXO3A was found to be associated with longevity [19196970]. Human
    UCP3 uncoupling protein 3 (mitochondrial, proton carrier) UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. Human
    UCP1 uncoupling protein 1 (mitochondrial, proton carrier) UCP1 was found to be associated with longevity [21827845]. Human
    UCK2 uridine-cytidine kinase 2 UCK2 was found to be associated with longevity [22445811]. Human
    UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) UCHL1 is assoicated with Parkinson's disease [9774100]. UCHL1 belongs to a family of de-ubiquitinating enzymes responsible for the hydrolysis of bonds between ubiquitin molecules and small adducts [11084366]. Decreased activity due to mutation may result in decreased labeling of abnormal proteins for clearance. Human
    SOD1 superoxide dismutase 1, soluble Ubiquitous overexpression of SOD1 does not extend lifespan in mice. Homozyous transgenic mice with two- to five-fold overexpression of SOD1 in various tissues exhibit a light reduction in lifespan. Hemizygous transgenic mice, with 1.5- to 3-fold overexpression of SOD1 display no difference in lifespan compared with nontransgenic litermate controls [10719757]. Transgenic mice with a mutant SOD1 transgene develop neuronal cytoskeletal lesions resembling the human amytrophic lateral sclerosis (ALS) phenotype [8610185]. Transgenic mice overexpressing SOD1 (and having 3.1-fold higher cellular Cu,Zn SOD activity in the brain) have reduced infarct size following experimental cerebral ischemia [1763030].SOD1 was not found to be associated with longevity [24163049]. Human
    UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast) UBE2H was found to be associated with longevity [22279548]. Human
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    • 25 of 724 factors
    Factors are an extension of GenAge and GenDR.

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