| iftb-1 | eIFTwoBeta (eIF2beta translation initiation factor) | RNAi knockdown of iftb-1 at 25.5 degree Celsius continuously extends mean and maximum lifespan by 13 and 11%, while knockdown only during the adulthood extends mean and maximum lifespan by 16 and 6% [16720740]. RNA interference if iftb-1 in adulthood increases maximum lifespan by about 30% [17266679]. | Nematode |
| daf-10 | abnormal DAuer Formation 10 | Loss of function mutation in daf-10 increases lifespan by 60% (in Bristol N2) [10617200]. daf-10 mutants are dauer defective, dye filling defective, octopamine deficient and have abnormal chemotaxis and osmotic avoidance. Mutants in daf-10 display abnormal sensory anatomy, especially amophidial neurons and sheath cells, and cephalic neurons. daf-10 mutant males do not mate [2428682]. | Nematode |
| ctbp-1 | CTBP (CtBP) transcriptional co-repressor homolog | Genetic inactivation of ctbp-1 results in lifespan extension dependent on daf-16, but independent of sir-2.1. RNAi of lips-7(C09E8.2) suppresses lifespan extension by ctbp-1 inactivation [19164523]. | Nematode |
| shc-1 | SHC (Src Homology domain C-terminal) adaptor homolog | Loss of shc-1 function results in accelerated aging and enhanced senstivity ro heat, oxidative stress and heavy metals. | Nematode |
| tag-322 | Temporarily Assigned Gene name | tag-322 RNAi increases mean and maximum lifespan by 18 and 12%, respectively [19293945]. | Nematode |
| F13G3.10 | — | RNAi of F13G3.10 extends mean and maximum lifespan by 11 and 14%, respectively [19293945]. | Nematode |
| rps-27 | Ribosomal Protein, Small subunit | Knockdown of rps-27 by RNAi extends mean and maximum lifespan by 50 and 44%, respectively [19293945]. | Nematode |
| E01A2.2 | — | RNAi against E01A2.2 increases mean and maximum lifespan by 11 and 18%, respectively [19293945]. | Nematode |
| B0035.12 | — | RNAi of B0035.12 increases mean and maximum lifespan by 12 and 20%, respectively [19293945]. | Nematode |
| mak-2 | MAP kinase Activated protein Kinase | RNAi of mak-2 increases mean and maximum lifespan by 12 and 14% [19293945]. | Nematode |
| rict-1 | RICT0r (Rapamycin-Insensitive Companion of TOR) homolog | C. elegans with mutations in the TORC2 complex gene rict-1 (Rictor) grow slowly and have small body size, and live slightly longer than wild-type when maintained on ârichâ food such as the RNAi feeding strain HT115 and at elevuated temperature (25 degree Celsius) [Soukas et al., 2009 in (Robida-Stubbs et al., 2012)]. rict-1 RNAi at 20 degree Celsius in the adulthood increases mean, median, 75th %ile and maximum lifespan by 12-42, 22-29, 13-32 and 28-54%, respectively, dependent on skn-1. daf-16 is not required for lifespan to be increased by rict-1 RNAi, or when TORC1 and TORC2 are blocked by ragc-1;rict-1 RNAi. rict-1 RNAi extends mean, median, 75th %ile and maximum lifespan in the intestine-specific RNA stains VPS288 by 18, 19, 18 and 16%, respectively [22560223]. | Nematode |
| eif-1 | Eukaryotic Initiation Factor 1 | RNA interference against eif-1 in the adulthood extends mean lifespan by 25% [17411345]. eif-1 RNAi only during the adulthood increases mean, median and 75th %ile lifespan by 23-35, 38 and 22-40%, respectively [22560223]. | Nematode |
| raga-1 | RAs-related GTP-binding protein A | raga-1 RNAi only during adulthood increases mean, median, 75th %ile and maximum lifespan by 9-42, 26-28, 16-52 and 35%, respectively, but failed so in skn-1 or daf-16 mutant (with and without FUdR). Lifespan of the skn-1;daf-16 mutant was unaffected by raga-1 RNAi. Knockdown of raga-1 dramatically increases stress tolerance in an skn-1 but not daf-16-dependent manner [22560223]. | Nematode |
| ragc-1 | RAs-related GTP binding protein C homolog | ragc-1 RNAi only during adulthood increases mean, median and maximum lifespan by 13-33, 21 and 33-37% respectively, but failed so in skn-1 or daf-16 mutant (with and without FUdR). Interference with TORC1 by ragc-1 RNAi increases heat resistance in daf-16 and skn-1 mutants, but not not in skn-1;daf-16 double mutant. ragc-1 RNAi increases lifespan in a strain in which RNAi is restricted to the intestine (VP288). RNAi of ragc-1 decreases overall mRNA translation but increases autophagy (measured by LGG-1 puncta) [22560223]. | Nematode |
| hcf-1 | Host Cell Factor-1 | hcf-1 is conserved protein [12826401], ubiquitously expression in C. elegans under normal culture conditions and predominantly nuclear [7876203]. HCF-1 forms a complex with DAF-16. hcf-1 inactivation by mutation cause a daf-16-dependent lifespan extension of up to 40% and heightened resistance to specific stimuli. The hcf-1(ok559) mutation increases mean and maximum lifespan by 10-37 and 29%, while the strong hcf-1(pk924) mutation extends mean and maximum lifespan by 29-31 and 53-88%, respectively. In the absence of hcf-1 there is a greater enrichment of DAF-16 at its target gene promoters and more robust DAF-16-mediated regulation of selective transcriptional targets. hcf-1 mutation extends lifespan of glp-1(e2141) mutants which lack germline cells, [18828672].
SKN-1 contributes to the enhanced oxidative stress resistance incurred by hcf-1 mutation. HCF-1 prevents the nuclear accumulation of SKN-1 and represses the transcriptional activation of SKN-1 specifically at target genes involved in cellular detoxification [22568582]. | Nematode |
| ncbp-2 | Nuclear Cap-Binding Protein | RNAi against ncbp-2 decreases mean and maximum lifespan by 23-25% and 7%, respectively [18059442]. | Nematode |
| max-2 | Motor AXon guidance 2 | RNAi against max-2 increases mean lifespan by 21-29% [18059442]. | Nematode |
| R03D7.4 | — | RNAi against R03D7.4 increases mean and maximum lifespan by 9-17% and 7%, respectively [18059442]. | Nematode |
| fzy-1 | FiZzY (CDC20 protein family) homolog | RNAi against fzy-1 increases mean and maximum lifespan by 17-32% and 14%, respectively [18059442]. | Nematode |
| bub-3 | yeast BUB homolog | RNAi against bub-3 increases mean and maximum lifespan by 6-7% and 7%, respectively [18059442]. | Nematode |
| prx-11 | PeRoXisome assembly factor | RNAi against prx-11 increases mean and maximum lifespan 11% [22509016]. | Nematode |
| prx-13 | PeRoXisome assembly factor | Knockdown of prx-13 increases mean and maximum lifespan by 17% (28%!) and 11% respectively. prx-13 knockdown from hatching does no effect [22509016]. | Nematode |
| F18F11.1 | — | F18F11.1 knockdown extends mean lifespan by 17% and 11%, respectively [22509016]. | Nematode |
| par-6 | Partitioning defective protein 6 | par-6 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| let-92 | LEThal | let-92 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
