| hpd-1 | 4-HydroxyPhenylpyruvate Dioxygenase (HPD)) 1 | RNAi knockdown of hpd-1 starting at hatching or only during the adulthood significantly extends lifespan of both wild-type and eat-2 [22810224]. | Nematode |
| fat-2 | FATty acid desaturase 2 | RNAi knockdown of fat-2 starting at hatching or only during the adulthood significantly extends lifespan of wild-type, but does not alter, or even shortens the lifespan of eat-2 mutants. FAT-2 is downregulated in eat-2 [22810224].
| Nematode |
| pyk-1 | PYruvate Kinase 1 | RNA interference of pyk-1 during adulthood significantly shortens the lifespan of both wild-type and eat-2 mutants. RNAi knockdown of pyk-1 from hatching causes larval lethality. PYK-1 is downregulated in eat-2 mutants [22810224].
pyk-1(ok1754) mutation extends the lifespan and this effect is non-additive with the lifespan extension mediated by DDS treatment [20974969]. | Nematode |
| SIT4 | Suppressor of Initiation of Transcription 4 | SIT4 deletion slightly increases chronological lifespan and totally abolishes the lifespan shortening due to ISC1 deletion [21707788]. | Budding yeast |
| ATH1 | Acid TreHalase | Deletion of ATH1 extend the mean chronological lifespan by 17% (at 30 degree Celsus in BY4742) [22783207].
ATH1 mutants have higher trehalose levels until the end of the post-diauxic growth phase, but reaches a plateau at the level of 50-70% of wild-type in the stationary phase [22783207]. | Budding yeast |
| TPS3 | Trehalose-6-Phosphate Synthase 3 | Deletion of TPS3 extend the mean chronological lifespan by 39% (at 30 degree Celsus in BY4742) [22783207].
TPS3 mutants have higher trehalose levels until the end of the post-diauxic growth phase, but reaches a plateau at the level of 50-70% of wild-type in the stationary phase [22783207]. | Budding yeast |
| TSL1 | Trehalose Synthase Long chain 1 | Deletion of TSL1 extends the mean chronological lifespan by 43% (at 30 degree Celsus in BY4742) [22783207].
Mutant TSL1 cells have reduced oxidative carbonylation of cellular proteins throughout lifespan. TSL1 mutants have higher trehalose levels, but reaches a plateau at the level of 50-70% of wild-type in the stationary phase. TSL1 deletion cells have no altered ROS levels in pre-quiescent cells [22783207]. | Budding yeast |
| ins-35 | INSulin related 35 | ins-35 encodes an insulin-like peptide which is downregulated in space. Mutation or RNA interference of ins-35 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. ins-35 RNAi extends mean, 75%ile, and maximum lifespan by 8, 4, and 32%. ins-35(TM290) mutation extends mean, 75%ile, and maximum lifespan by 15-17, 14-23, and 23-24%. Lifespan extension by ins-35 mutation is totally abolished by daf-16 or skn-1 RNAi inactivation eat-2 RNAi further enhances the extension of lifespan by mutation in ins-35 [22768380].
Mutation and RNAi of ins-35 enhance pheromone-induced dauer formation [22768380].
| Nematode |
| shk-1 | SHaKer family of potassium channels 1 | shk-1 encodes a shaker family of potassium channel which functions in muscle [21059759], is expressed in sensory neurons [16899454], and downregulated in space. Mutation or RNA interference of shk-1 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. shk-1 RNAi extends mean, 75%ile, and maximum lifespan by 16, 15, and 22%. shk-1(RB1392) mutation extends mean, 75%ile, and maximum lifespan by 19-22, 19-21, and 20-24%. Lifespan extension by unc-17 mutation is totally abolished by RNAi inactivation of either daf-16 or skn-1. eat-2 RNAi shortens the lifespan of shk-1 mutants. RNAi inactivation of shk-1 reduces Q35 aggregation [22768380].
Mutation and RNAi of shk-1 enhance pheromone-induced dauer formation [22768380].
| Nematode |
| glc-4 | Glutamate-gated ChLoride channel 4 | glc-4 encodes a glutamate-gated chloride channel which is expressed in sensory neurons [17850180] and is downregulated in space. Mutation or RNA interference of glc-4 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. glc-4 RNAi extends the mean, 75%ile, and maximum lifespan by 13, 11, and 19%. glc-4(JD31) increases the mean, 75%ile, and maximum lifespan by 13-23, 11-23, 19-34%. Lifespan extension by glc-4 mutation is totally abolished by RNAi inactivation of either daf-16 or skn-1. eat-2 RNAi further enhances the extension of lifespan by glc-4 mutation [22768380].
Mutation and RNAi of glc-4 suppresses pheromone-induced dauer formation [22768380].
| Nematode |
| F57A8.4 | Protein F57A8.4 | F57A8.4 encodes a rhodopsin-like G-protein coupled receptor that is known to sense light [11493519] and is downregulated in space.
Mutation or RNA interference of F57A8.4 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. F57A8.4 RNAi extends the mean, 75%ile and maximum lifespan by 34, 39, and 61%. F57A8.4(tm4341) mutation extends the mean, 75%ile, and maximum lifespan by 18-38, 21-25, and 42-68%. Lifespan extension by gar-3 mutation is not abolished by RNAi inactivation of either daf-16 nor skn-1. eat-2 RNAi shortens the lifespan of F57A8.4 mutants [22768380].
Mutation and RNAi of F57A8.4 suppresses pheromone-induced dauer formation [22768380].
| Nematode |
| cha-1 | abnormal CHoline Acetyltransferase 1 | cha-1 encodes a choline acetyltransferase which is expressed in motor [18041778] neurons and downregulated in space. Mutation or RNA interference of cha-1 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium [22768380]. cha-1(TY1652) mutation extends mean, 75%ile, and maximum lifespan by 23, 29, and 38%. The cha-1(PR1152) allele extends mean, 75%ile, and maximum lifespan by 22-49, 18-25, and 11-21%. Lifespan extension by cha-1 mutation is not abolished by daf-16 RNAi inactivation. eat-2 RNAi shortens the lifespan of cha-1 mutants. RNAi inactivation of cha-1 reduces Q35 aggregation [22768380].
cha-1 participates in determining pharyngeal pumping rate to affect food intake [6698395]. | Nematode |
| unc-17 | UNCoordinated 17 | unc-17 encodes acteylcholine transporter which is expressed in motor [18041778] and inter-neurons and is downregulated in space. Mutation of unc-17 extends lifespan on NGM agar covered with killed or live bacteria. nc-17(CB933) extends mean, 75%ile, and maximum lifespan by 31-79%, 68-89%, and 68-79%. Lifespan extension by unc-17 mutation is totally abolished by RNAi inactivation of daf-16, but not skn-1. eat-2 RNAi further enhances the extension of lifespan by mutations of unc-17 [22768380].
Mutation and RNAi of unc-17 suppresses pheromone-induced dauer formation [22768380].
| Nematode |
| gar-3 | G-protein-linked Acetylcholine Receptor 3 | gar-3 encodes a acetycholine receptor which is expressed in motor neurons and muscle [17287516], participates in acetylcholine transmission in motor neuron-muscle signalling, and is downregulated in space. Mutation or RNA interference of gar-3 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. gar-3 RNAi extends mean, 75%ile, and maximum lifespan by 11, 14 an 17%. gar-3(VC670) mutation extends mean, 75%ile, and maximum lifespan by 5-18, 4-7 and 15-56%. Lifespan extension by gar-3 mutation is not abolished by RNAi inactivation of daf-16, skn-1, or eat-2. RNAi inactivation of gar-3 reduces Q35 aggregation [22768380]. | Nematode |
| tdp-1 | TAR DNA-binding Protein homolog 1 | tdp-1(ok803) mutation increases mean and maximum lifespan at 20 degree Celsius but not at 25 degree Celsius. tdp-1(ok803) reduce the lifespan of daf-2(e1370) mutants, but does not does not reduces the lifespan of daf-16(mu86) mutants. RNAi against tdp-1 reduces lifepsna of daf-2(e1370) mutants. tdp-1 overexpression strains have a reduced lifespan at 20 and 25 degree Celsius [Vaccaro et al. 2012]. | Nematode |
| IRC14 | — | Deletion of IRC14 increases mean replicative lifespan by 14-22% [16293764].
IRC14 is a dubious ORF overlapping IDH2. | Budding yeast |
| WRKY6 | WRKY transcription factor 6 | Deletion of the WRKY6 promoter results in defects in root and leaf cell senescence [11722756].
WRKY6 is a transcription factor involved in controlling processes related to senescence and pathogen defence [11722756] and is a positive regulator of PR1 expression [12000796]. WRKY6 is strongly expressed during senescence [11722756]. | — |
| spe-10 | defective SPErmatogenesis family member (spe-10) | Mutation of spe-10 results in a 20% increase in mean lifespan on solid media [2744235].
spe-10 mutants have a temperature sensitive defect in sperm development and their lifespan correlates with thermoterance and UV resistance [2744235]. | Nematode |
| SAG101 | senescence-associated protein 101 | Antisense RNA interference of SAG101 in transgenic plants delays the onset of leaf senescence for approximately 4 days, whereas chemical induced overexpression of SAG101 causes precocious senescence in both attached and detached leaves of transgenic plants [11971136]. | — |
| rad-8 | RADiation sensitivity abnormal/yeast RAD-related 8 | Mutation of rad-8 increases lifespan by approximately 30% at 16 degree Celsius but not at 20 degree Celsius [8169328]
rad-8 mutants are hypersensitive to UV radiation, but not X-rays or MMS [7152245] | Nematode |
| PLD alpha | — | Antisense suppression of PLD alpha retards abscisic acid- and ethylene-induced senescence. Leaves detached from PLD alpha-deficient transgenic plants when inbutated in abscisic acid and ethylene exhibit a slower rate of senescence that those from wild-type and transgenic controls. PLD alpha deficient strains are associated with retardation of senescence as evidenced by delayed leaf yellowing, lower ion leakage, greater photosynthetic activity, and higher content of cholorophyl and phospholipids [9437863].
Antisense suppression of PLD alpha does not affect natural plant growth and development [9437863]. | — |
| MORF4 | mortality factor 4 | Overexpression of MORF4 reverses the immortal phenotype of immortal cell lines in complementation group B [9891081]. Cellular senescence is dominant over immortality in fused hybrids of normal and immortal human cell in culture [6879195]. Fusion of immortal cell lines with each other led to the idenetification of four complementation groups for immortality [3413074]. MORF4 rescues the immortal phenotype [9891081]. | Human |
| LMNA | lamin A/C | Dominant mutation in LMNA (lamin A/C) gene cause Hutchinson-Gilford progeria syndrome (HGPS) which is rare and characterized by prematurly senile appearing skin and hair, with death from coronary artery disease often by age 10 [Gilford 1904; Hutchinson 1886; OMIM]. The median age of death in HGPS individuals is 13.4 years. A C to T transition at nucleotide 1824 is associated with HGPS [Sandra-Giovannoli et al., 2003; Eriksson et al., 2003]. The 1824C-T allele appears to act in a dominant negative manner by interfering with normal splicing, resulting in production of both the normal transcript and a transcript deleted for 150 bp at the 3' end [Sandre-Giovannoli et al, 2003]. Cultured skin fibroblasts from individuals with progeria exhibit an increased fraction of hat-labile proteins [1128606].
Gilford (1904). Ateleiosis and progeria: continuous youth and premature old age. Brit Med J 2, 914-918.
Hutchinson, J. (1886). Case of congenital absence of hair, with atrophic condition of the skin and its appendages, in a boy whose mother had been almost wholly bald from alopecia areata from the age of six. Lancet 1, 923.LMNA was found to be associated with longevity [22340368]. LMNA was found to be associated with longevity [22340368]. LMNA was found to be associated with longevity [22279548]. LMNA was found to be associated with longevity [24244950]. | Human |
| AFUA_1G13190 | copper-activated transcription factor GRISEA | In Grisea (AFUA_1G13190) loss of function mutants, senescence is delayed two-fold [8804410].
Grisea disruption extends mean and maximum lifespan by 195 and 210% [17173038].
Grisea mutant has altered norphology and defects in formation of female gametangia [9380708]. | Podospora anserine |
| Gh1 | growth hormone 1 | Animals carrying a single copy of an anti-sense Gh1 transgene (tg/-) live on average 7-10% longer. However, animals carrying two copies of the transgene (tg/tg) have a slighlty shorter lifespan compared to -/- animals, indicating that an optimal dosage of Gh1 is nessary to achieve lifespan exentension and too little GH has a detrimental effect on longevity. tg/tg and tg/- animals are dwarfs and exhibit reduced levels of serum IGF1 [12057928]. | Norway rat |
