Denigma

HLA-DQA1

Symbol: HLA-DQA1
Name: major histocompatibility complex, class II, DQ alpha 1
Entrez gene ID: 3117
Ensembl gene ID: ENSG00000196735
Species: Human (Taxid: 9606)


Observation:

olymorphisms in HLA class II alleles of Okinawan centenarians were analyzed. DQA10101=0104 and DQA105 alleles were significantly increased in the centenarians [9389323].HLA-DQA1 was found to be associated with longevity [9389323]. HLA-DQA1 was found to be associated with longevity [9389323]. HLA-DQA1 was not found to be associated with longevity [17714903].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • DQA1*01;DQA1*02;DQA1*03;DQA1*04;DQA1*05;DQA1*06 None [17714903]
  • HLA-DQA1 haplotypes 0.04 [9389323]
  • HLA-DQA1 haplotypes 0.038 [9389323]

    • Classification:
  • Longevity-Associated
  • No Age Effect


    • Type:
  • Gene
  • Protein coding

    References:
  • 9389323: Molecular genetic studies on DNA polymorphism of the HLA class II genes associated with human longevity.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • HLA-DQA1 (9606)
  • H2-Aa (10090)
  • RT1-Ba (10116)



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