Polymorphism: HLA-DQA1 haplotypes
Location: 6p21.3
Factor:
- Symbol: HLA-DQA1
- Name: major histocompatibility complex, class II, DQ alpha 1
- Entrez ID: 3117
- Ensembl ID: ENSG00000196735
Factors:
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
(
3117
/
ENSG00000196735
)
Description:
The increased frequency DQA10101=0104 can be explained by a LD with DRBl1401 or vice versa, which was also significantly frequent in them, because DRB11401-DQB10503-DQA10104 is one of the prominent haplotypes in Okinawan Japanese. Alleles that were significant before but not after corrected P value test: Decreased in centenarians (HLA-DQA10102, HLA-DQA1*0103). Note: related to rs6457617?
odds_ratio = RR = 1.739 (could not convert string to float: RR = 1.739)
Ethnicity:
Okinawan
Age of cases: Mean age 102.3 +/- 1.9 years
Shorter lived allele: non-HLA-DQA1*0101=0104 alleles
Longer lived allele: HLA-DQA1*0101=0104
Statistics
- Number of cases/controls: 120 vs 129 (initial)
- p-value:
0.04
[0.04]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology:
Reference:
9389323: Molecular genetic studies on DNA polymorphism of the HLA class II genes associated with human longevity.
Choice: Curate
Created: July 1, 2013, 1:04 p.m.
Updated: Aug. 8, 2014, 1:05 p.m.
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