Symbol: rpn-11 Name: proteasome Regulatory Particle, Non-ATPase-like 11 Alias: WBGene00004467 Entrez gene ID: 173744 Ensembl gene ID: K07D4.3 Species: Worm (Taxid: 6239) Functional description: Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity). [UniProt] Observation: rpn-11 RNAi in the adulthood decreases mean and maximum lifespan by 19 and 25%, respectively [23144747]. Interventions: Assays: Organismal Lifespan Mean: -19.3 Maximum: -25.0 Classification: References: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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