Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks.

Authors: Tacutu R; Shore DE; Budovsky A; de Magalhães JP; Ruvkun G; Fraifeld VE; Curran SP

Abstract: Intricate and interconnected pathways modulate longevity, but screens to identify the components of these pathways have not been saturating. Because biological processes are often executed by protein complexes and fine-tuned by regulatory factors, the first-order protein-protein interactors of known longevity genes are likely to participate in the regulation of longevity. Data-rich maps of protein interactions have been established for many cardinal organisms such as yeast, worms, and humans. We propose that these interaction maps could be mined for the identification of new putative regulators of longevity. For this purpose, we have constructed longevity networks in both humans and worms. We reasoned that the essential first-order interactors of known longevity-associated genes in these networks are more likely to have longevity phenotypes than randomly chosen genes. We have used C. elegans to determine whether post-developmental inactivation of these essential genes modulates lifespan. Our results suggest that the worm and human longevity networks are functionally relevant and possess a high predictive power for identifying new longevity regulators.

Journal: PloS one
Volume: 7
Issue: 10
Pages: e48282
Date: Nov. 13, 2012
PMID: 23144747
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Tacutu R, Shore DE, Budovsky A, de Magalhães JP, Ruvkun G, Fraifeld VE, Curran SP (2012) Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks. PloS one 7: e48282.

Study Lifespan Factors:
  • T23D8.3 More Of MS
  • rps-14 Ribosomal Protein, Small subunit
  • lin-5 abnormal cell LINeage
  • rnr-2 RiboNucleotide Reductase
  • rps-12 Ribosomal Protein, Small subunit
  • F09F7.3 NEK (NEver in mitosis Kinase) Like
  • mel-28 Maternal Effect Lethal 28
  • asb-1 ATP Synthase B homolog
  • hmg-4 HMG 4
  • rpb-8 RNA Polymerase II (B) subunit 8
  • C47D12.2 TRRAP-like (transcription/transformation domain-associated protein)
  • gpd-3 GPD (glyceraldehyde 3-phosphate dehydrogenase) 3
  • pcf-11 cleavage and polyadenylation factor homolog 11
  • rpn-11 proteasome Regulatory Particle, Non-ATPase-like 11
  • cdtl-7 CDc-Two Like 7
  • dpy-27 DumPY : shorter than wild-type 27
  • gei-4 GEX Interacting protein 4
  • R02D3.3
  • emb-27 abnormal EMBroygenesis 27
  • aps-1 AdaPtin, Small chain (clathrin associated complex) 1
  • chn-1 C-term of Hsp70-iNteracting protein (CHIP family) 1
  • rsr-1 SR protein related 1
  • rpa-1 Replication Protein A homolog 1
  • nhr-23 Nuclear Hormone Receptor family 23
  • sptf-3 Specificity Protein Transcription Factor 3
  • pat-3 Paralysed Arrest at Two-fold 3
  • rpt-1 proteasome Regulatory Particle, ATPase-like 1
  • rab-5 RAB family 5
  • snap-1 SNAP (Soluble NSF Attachment Protein) 1
  • snap-29 SNAP (Soluble NSF Attachment Protein) homolog 29

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