DAF-16 target genes that control C. elegans life-span and metabolism.

Authors: Lee, Siu Sylvia; Kennedy, Scott; Tolonen, Andrew C; Ruvkun, Gary
Year: 2003
Journal: Science
Abstract: Signaling from the DAF-2/insulin receptor to the DAF-16/FOXO transcription factor controls longevity, metabolism, and development in disparate phyla. To identify genes that mediate the conserved biological outputs of daf-2/insulin-like signaling, we used comparative genomics to identify 17 orthologous genes from Caenorhabditis and Drosophila, each of which bears a DAF-16 binding site in the promoter region. One-third of these DAF-16 downstream candidate genes were regulated by daf-2/insulin-like signaling in C. elegans, and RNA interference inactivation of the candidates showed that many of these genes mediate distinct aspects of daf-16 function, including longevity, metabolism, and development.
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Created on Nov. 5, 2012, 5:56 p.m.
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Integrated: False

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Species: Nematode

Experiments: 0
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