Symbol: irs-1 Name: Isoleucyl tRNA Synthetase Alias: Isoleucyl tRNA Synthetase family member (irs-1);WBGENE00002152 Entrez gene ID: 177926 Ensembl gene ID: R11A8.6 Species: Worm (Taxid: 6239) Functional description: Isoleucyl tRNA Synthetase; Protein IARS-1; Serine/threonine-protein kinase sax-1 [Source:UniProtKB/Swiss-Prot;Acc:Q2L6W9] [Ensembl]; irs-1 encodes a predicted cytoplasmic isoleucyl-tRNA synthetase (IleRS), an aminoacyl-tRNA synthetase that catalyzes the attachment of isoleucine to its cognate tRNA and is thus required for protein biosynthesis; loss of irs-1 activity via RNA-mediated interference (RNAi) results in sterility, embryonic lethality, and slower rates of growth, indicating that IRS-1 is essential for development. [WormBase] Observation: irs-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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