Symbol: MEC1 Name: Mitosis Entry Checkpoint 1 Alias: ESR1; SAD3; RAD31 Entrez gene ID: 852433 Ensembl gene ID: YBR136W Species: Yeast (Taxid: 4932) Functional description: Involved in replication stress and DNA damage; Mec1p; Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination [Source:SGD;Acc:S000000340] [Ensembl]; Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres [SGD] Observation: MEC1 mutants have a 3-fold reduced mean and maximum chronological lifespan under conditions of medium depletion [17710147]. Interventions: Assays: Chronological Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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