Symbol: IDH2
Name: Isocitrate DeHydrogenase 2
Entrez gene ID: 854303
Ensembl gene ID: YOR136W
Species: Yeast
(Taxid: 4932)
Functional description:
Idh2p; Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated [Source:SGD;Acc:S000005662] [Ensembl]
Observation:
Deletion of IDH2 increases the mean replicative lifespan by about 30% [16293764]. IDH2 deletion extends mean replicative lifespan by 20% in the alpha strain and in a strain [19030232; 18340043]. IDH2 deletion extends mean, median and maximum lifespan by 5, 19 and 15% [23167605].
Interventions:
IDH2 deletion
+15.4 to +30%
+19.2%
+15.4%
Assays:
Replicative Lifespan
Mean: +15.4 to +30
Median: +19.2
Maximum: +15.4
Classification:
Aging-Suppressor
Negative Aging-Suppressor
References:
18340043: Quantitative evidence for conserved longevity pathways between divergent eukaryotic species.
16293764: Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients.
19030232: Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity.
23167605: Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging.
Aging Relevance Analysis/Source:
GenAge
GenDR
Homologs
IDH3A
(9606)
IDH3A
(9598)
IDH3A
(9615)
IDH3A
(9913)
Idh3a
(10090)
Idh3a
(10116)
IDH3A
(9031)
idh3a
(7955)
l(1)G0156
(7227)
AgaP_AGAP002728
(7165)
F43G9.1
(6239)
idh2
(4896)
IDH2
(4932)
KLLA0E03125g
(28985)
AGOS_AFR137C
(33169)
GeneID:2679352
(148305)
NCU07697
(5141)
AT5G03290
(3702)
AT3G09810
(3702)
Os01g0276100
(4530)
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