Denigma

IDH2 deletion

Species: Budding yeast (Taxid: 4932)
Factor: IDH2
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Deletion of IDH2 increases the mean replicative lifespan by about 30% [16293764]. IDH2 deletion extends mean replicative lifespan by 20% in the alpha strain and in a strain [19030232; 18340043]. IDH2 deletion extends mean, median and maximum lifespan by 15, 19 and 15% [23167605].

Mean: +15.4 to +30
Median: +19.2
Maximum: +15.4

References:
  • 18340043: Quantitative evidence for conserved longevity pathways between divergent eukaryotic species.
  • 16293764: Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients.
  • 19030232: Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity.
  • 23167605: Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR
    • Comparisons:
  • idh2 vs. wild-type ( 30°C ) : 15.4(mean) 19.2(median) 15.4(max) 4.1e-11(p-value)

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