Symbol: Eip71CD Name: Ecdysone-induced protein 28/29kD Alias: CG7266; Dmel\CG7266; DROZ60MEX; Eip28; Eip28 /29; eip28/29; Eip28/29; Eip71C; MsrA Entrez gene ID: 39675 Ensembl gene ID: FBgn0000565 Species: Fly (Taxid: 7227) Functional description: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. [UniProt] Observation: Overexpression of Eip71CD (alias MsrA) in nervous system extends the lifespan by up to 70%, increased resistance to oxidative stress, and delays the onset of senescence-induced decline in activity levels and reproductive capacity. Eip71CD is a downstream effector of foxo [22310715]. Mean and maximum lifespan is increased by up to 2-% in animals that overexpress Eip71CD [20655917]. Interventions: Assays: Organismal Lifespan Mean: +20 to 70 Maximum: +20 Classification: Type: References: Aging Relevance Analysis/Source: Homologs Inparanoids Note: Not sure if 70% refers to mean lifespan. Just a guess. GenAge has typo in "lifespan". Edit \ Update (Admin) | Delete |
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