Symbol: dkf-2 Name: D Kinase Family Entrez gene ID: 180121 Ensembl gene ID: T25E12.4 Species: Worm (Taxid: 6239) Functional description: Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Acts in the intestine to regulate both innate immunity by promoting activation of PMK-1 and also stress response and life span by acting as an upstream, negative regulator of the daf-16 transcription factor. [UniProt] Observation: Adult median and maximal lifespan increases by 40% and 20%, respectively, in animals lacking dkf-2. dkf-2 deficiency also ameliorated heat stress. Assays: Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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