Symbol: phb-1 Name: mitochondrial ProHiBitin complex 1 Entrez gene ID: 171768 Ensembl gene ID: Y37E3.9 Species: Worm (Taxid: 6239) Functional description: PHB proteins are essential during embryonic development and are required for somatic and germline differentiation in the larval gonad. A deficiency in PHB proteins results in altered mitochondrial biogenesis in body wall muscle cells. [UniProt] Observation: phb-1 RNAi shortens lifespan of wild-type, aak-2, cep-1 (p53) and jnk-1 mutants, but increases lifespan of daf-2, daf-7, daf-4, daf-11, gas-1, mev-1, isp-1, clk-1, nhr-49, fat-7 and gld-1 mutants. daf-16 mutation fully suppressed the exceptional long-lifespan of prohibitin-depleted (via RNAi) daf-2 mutants [19812672]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Orthologs Edit \ Update (Admin) | Delete |
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