About
Objective
Purpose
Concepts
Philosophy
ILA
GCI
What Next?
Matrix
Terms
Privacy
Aspects
Facets
Research
Programming
Design
Professions
Scientist
Developer
Artist
Achievements
Ranks
Grades
Titles
Content
Data/Entries/Relations
Blog/Posts/Comments
Wiki/Pages/Tags
Articles (Reports/Reviews)
Ontology
Tutorials
Links
Media
Polls
Questionnaires
Repository
Annotations
Classifications
Tissues
Species
Interactions
Expressions
Profiles
Signatures
Intersections
Sets
Meta
Datasets
Create
References
Archive
Changes
Lifespan
Studies
Experiments
Measurements
Comparisons
Interventions
Factors
Variants
Assays
Strains
Regimens
Manipulations
Epistases
Experts
Profiles
Collaborations
Com
Messaging
Announcements
Video
Donate
Log in
or
Sign up
Denigma
>
Wiki
> Page = MolecularProfiling > Edit
o
Start
|
Search
|
Index
Mouse Lifespan Experiments
(
Hide
)
Wiki
MolecularProfiling - Editing
leave this field blank to prove your humanity
Virtually all physiological function of tissues or organs decline with increasing age. Ageing-differentially expressed genes exhibit a clear tissue-specific pattern. < 10% of them in each tissue were in common with any other tissue and < 10% of biological processes were in common with any other tissue [17623811]. Critical changes of the transcriptional levels generally occurs after 30 days of age, some as late as 60 days, indicating that aging gene expression changes are a gradual process [17623811]. SdhB, ATP synthase, ferritin and aconitase in nematode [Hamilton et al. 2005; Hansen et al. 2005] and Indy and SdhB in fruit fly [Rogina et al. 200; Walker et al. 2006] modulate lifespan. Reducing expression of IIS genes such as daf-2 in the adult stage alone lifespan [Dillin et al. 2002]. Genome-wide transcriptional studies on aging in invertebrates [Zou et al. 2000; Lund et al. 2002; Pletcher et al. 2002; Landis et al. 2004; Wang et al. 2004; Kim et al. 2005; Girardot et al. 2006; Golden & Melov, 2004; McCarroll]. Comparison of aging profiles among different tissues [Fraser et al. 2005; Zhan et al. 2006]. Comparison of aging profiles among different species found alterations in transcripts encoding mitochondrial and proteasomal functions [McCarroll et al. 2004]. References --------------- Hamilton, B., Dong, Y., Shindo, M., Liu, W., Odell, I., Ruvkun, G., and Lee, S.S. 2005. A systematic RNAi screen for longevity genes in C. elegans. Genes & Dev. 19: 1544–1555. Hansen, M., Hsu, A.L., Dillin, A., and Kenyon, C. 2005. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet. 1: e17. doi: 10.1371/journal.pgen.0010017. Rogina, B., Reenan, R.A., Nilsen, S.P., and Helfand, S.L. 2000. Extended life-span conferred by cotransporter gene mutations in Drosophila. Science 290: 2137–2140. Walker, D.W., Hajek, P., Muffat, J., Knoepfle, D., Cornelison, S., Attardi, G., and Benzer, S. 2006. Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant. Proc. Natl. Acad. Sci. 103: 16382–16387 Dillin, A., Crawford, D.K., and Kenyon, C. 2002. Timing requirements for insulin/IGF-1 signaling in C. elegans. Science 298: 830–834. Zou, S., Meadows, S., Sharp, L., Jan, L.Y., and Jan, Y.N. 2000.Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. Proc. Natl. Acad. Sci. 97: 13726–13731. Lund, J., Tedesco, P., Duke, K., Wang, J., Kim, S.K., and Johnson, T.E. 2002. Transcriptional profile of aging in C. elegans. Curr. Biol. 12: 1566–1573. Pletcher, S.D., Macdonald, S.J., Marguerie, R., Certa, U., Stearns, S.C., Goldstein, D.B., and Partridge, L. 2002. Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster. Curr. Biol. 12: 712–723. Landis, G.N., Abdueva, D., Skvortsov, D., Yang, J., Rabin, B.E., Carrick, J., Tavare, S., and Tower, J. 2004. Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster. Proc. Natl. Acad. Sci. 101: 7663–7668. Wang, H.D., Kazemi-Esfarjani, P., and Benzer, S. 2004. Multiple-stress analysis for isolation of Drosophila longevity genes. Proc. Natl. Acad. Sci. 101: 12610–12615. Kim, S.N., Rhee, J.H., Song, Y.H., Park, D.Y., Hwang, M., Lee, S.L., Kim, J.E., Gim, B.S., Yoon, J.H., Kim, Y.J., et al. 2005. Age-dependent changes of gene expression in the Drosophila head. Neurobiol. Aging 26: 1083–1091. Girardot, F., Lasbleiz, C., Monnier, V., and Tricoire, H. 2006. Specific age related signatures in Drosophila body parts transcriptome. BMC Genomics 7: 69. doi: 10.1186/1471-2164-7-69. Fraser, H.B., Khaitovich, P., Plotkin, J.B., Paabo, S., and Eisen, M.B. 2005. Aging and gene expression in the primate brain. PLoS Biol. 3: e274. doi: 10.1371/journal.pbio.0030274. Zahn, J.M., Sonu, R., Vogel, H., Crane, E., Mazan-Mamczarz, K., Rabkin, R., Davis, R.W., Becker, K.G., Owen, A.B., and Kim, S.K. 2006. Transcriptional profiling of aging in human muscle reveals a common aging signature. PLoS Genet. 2: e115. doi: 10.1371/journal.pgen.0020115.eor. Golden, T.R. and Melov, S. 2004. Microarray analysis of gene expression with age in individual nematodes. Aging Cell 3: 111–124. McCarroll, S.A., Murphy, C.T., Zou, S., Pletcher, S.D., Chin, C.S., Jan, Y.N., Kenyon, C., Bargmann, C.I., and Li, H. 2004. Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nat. Genet. 36: 197–204.
Tags: