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Mouse Lifespan Experiments
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AgingCauses - Editing
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Aging systems ----------------------- 1. Telomere shortening 2. Mitochondrial 3. Mutation accumulation 4. Senescence gene expression 5. Somatic atrophy a) Mitochondrial apoptosis b) Nuclear DNA fragmentation 6. Sex tissue atrophy Aging damages -------------------------- 1. Cancer-causing nuclear mutation/epimutations 2. Mitochondrial mutations 3. Intracellular aggregates 4. Extracellular aggregates 5. Cell loss 6. Cell senescence 7. Extracellular crosslinks
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