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Longevity DB
Genetic variants implicated in human longevity.
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polymorphism
factor
odds ratio
pvalue
initial number
replication number
Population
age of cases
shorter lived allele
longer lived allele
study type
reference
APOE e2/e3/e4
APOE
4.40
0.02
179
—
Finn
Minimum age 104
e3, e4
e2
Candidate Region/Gene
11213279
rs4986790
TLR4
—
0.61
273 vs 594
—
German
Mean age 97.9
—
—
Candidate Region/Gene
17493663
rs2590504
KIAA0649
—
0.00854
1173 vs 570
—
American
85-100
—
C
Genome-Wide Association Study
22533364
rs2927261
Intergenic
1.25
0.001146375
801 vs 914
—
Caucasian
Median age 104
G
A
Genome-Wide Association Study
22279548
rs2024714
CDH4
—
7.43e-05
1173 vs 570
—
American
85-100
—
C
Genome-Wide Association Study
22533364
rs4785393
PAPD5
1.36
0.000253223
801 vs 914
—
Caucasian
Median age 104
A
G
Genome-Wide Association Study
22279548
rs6519194
ATF4
—
0.41
206 vs 397
—
Japanese
95+
—
—
Candidate Region/Gene
23770741
rs41383
NLRC5
—
0.00455
1173 vs 570
—
American
85-100
—
C
Genome-Wide Association Study
22533364
rs7857137
Intergenic
1.27
0.000239219
801 vs 914
—
Caucasian
Median age 104
G
A
Genome-Wide Association Study
22279548
rs738288
ATF4
—
0.54
205 vs 396
—
Japanese
95+
—
—
Candidate Region/Gene
23770741
rs16975963
Noncoding
—
0.00713
1173 vs 570
—
American
85-100
—
G
Genome-Wide Association Study
22533364
rs4771711
Intergenic
1.24
0.000278415
801 vs 914
—
Caucasian
Median age 104
G
A
Genome-Wide Association Study
22279548
rs13008689
Intergenic
—
0.00686
1173 vs 570
—
American
85-100
—
A
Genome-Wide Association Study
22533364
rs12129750
VPS13D
1.06
0.007897685
801 vs 914
—
Caucasian
Median age 104
A
G
Genome-Wide Association Study
22279548
rs12786104
CBL
—
0.12
210 vs 398
—
Japanese
95+
—
—
Candidate Region/Gene
23770741
G/A-IGF1R, Gly/Asp-IRS2, and Ala/Val-UCP2 allele combination
—
3.19
0.0006
208 vs 514
—
Italian
Mean age 96
non-AAV allele combi
AAV allele combinati
Candidate Region/Gene
21340542
-
TH
—
0.045
202 vs 170 vs 82
—
Italian
100-105 (oldest of 3 age groups, see notes)
—
—
Candidate Region/Gene
11053670
rs3120819
Intergenic
—
0.00806
1173 vs 570
—
American
85-100
—
C
Genome-Wide Association Study
22533364
rs4596036
PREX1
1.12
0.00066782
801 vs 914
—
Caucasian
Median age 104
A
G
Genome-Wide Association Study
22279548
rs11217184
CBL
—
0.8
212 vs 396
—
Japanese
95+
—
—
Candidate Region/Gene
23770741
I/D (insertion/deletion)
ACE
—
0.33
560 vs 560
—
French
centenarians 100th year or beyond, mean age 103.1
—
—
Candidate Region/Gene
11280044
rs9876781
Noncoding
—
0.000868
1173 vs 570
—
American
85-100
—
A
Genome-Wide Association Study
22533364
rs10518725
WDR72
1.37
0.000207413
801 vs 914
—
Caucasian
Median age 104
A
G
Genome-Wide Association Study
22279548
rs2249466
CBL
—
0.9
207 vs 394
—
Japanese
95+
—
—
Candidate Region/Gene
23770741
rs2802288
FOXO3A
1.51
0.003
281 vs 195
—
Italian
90–108
G
A
Candidate Region/Gene
19415983
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25 of 1635 variants