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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs5491 ICAM1 5e-66 5036 American 28-70 TT, AT AA Genome-Wide Association Study 22174011
rs9330200 TUBB4B 6e-53 5036 American 28-70 AA, AT TT Genome-Wide Association Study 22174011
rs2292664 RIMBP2 1.4e-37 5036 American 28-70 CC, CG GG Genome-Wide Association Study 22174011
rs4420638 APOE 0.72 3.4e-36 7729 vs 16121 13060 vs 61156 European 90+ GWAS 24688116
rs4537545 IL6R 3e-18 308 American, European, Ashkenazi Jewish 75.7 Candidate Region/Gene 19249341
rs2075650 APOE 0.71 3.39e-17 403 vs 1670 4149 vs 7582 Dutch mean 94 e4 Genome-Wide Association Study 21418511
rs2075650 APOE 0.53 4.44e-16 2202 vs 2164 Caucasian 100 Meta-Analysis 24244950
rs4420638 APOC1 0.53 1.8e-10 763 vs 1085 754 vs 850 German Mean age 99.7 G Genome-Wide Association Study 21740922
rs2075650 TOMM40 2.07 2.36e-10 801 vs 914 253 vs 341 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
HRAS1 LASS1 (CGT) APOE 1.06e-09 68 vs 68 American Candidate Region/Gene 20569235
E2 / E3 / E4 APOE 1.2e-08 560 vs 560 French centenarians 100th year or beyond, mean age 103.1 E4 Candidate Region/Gene 11280044
rs2149954 1.10 1.74e-08 7729 vs 16121 13060 vs 61156 European 90+ GWAS 24688116
DRD4 7R allele DRD4 3.5e-08 310 vs 2909 European mean age 95.2 years Candidate Region/Gene 23283341
rs1528753 8.1e-08 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
rs4420638 APOE 9.6e-08 4445 total (each a part of sibship of 2-5 siblings) Caucasian, European 90 Genome-Wide Association Study 23286790
AAT M/Z/S AAT 0.18 1e-07 143 vs 255 vs 127 Italian Centenarians M, S Z Candidate Region/Gene 17048073
rs3129046 0.66 2.21e-07 763 vs 1085 754 vs 850 German Mean age 99.7 Genome-Wide Association Study 21740922
rs1610742 0.66 3.02e-07 763 vs 1085 754 vs 850 German Mean age 99.7 Genome-Wide Association Study 21740922
rs4936894 VWA5A 1.11 3.38e-07 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project American A Genome-Wide Association Study 21782286
HRAS1 LASS1 (CGT) APOE 6.91e-07 204 vs 251 American Candidate Region/Gene 20569235
rs970048 Intergenic 1.77 7.17e-07 3746 vs 5912 Dutch Mean age 94 G Genome-Wide Association Study 21418511
rs970048 Intergenic 1.77 7.17e-07 403 vs 1670 3746 vs 5912 Dutch Mean age 94 G Genome-Wide Association Study 21418511
HFE C282Y HFE 7.2e-07 35 vs 106 91-105 (< 50 versus >90) C Y Candidate Region/Gene 11857056
HRAS1 LASS1 (CGT) APOE 1e-06 79 vs 88 American Candidate Region/Gene 20569235
rs10493513 1.5e-06 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
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  • 25 of 1635 variants