Polymorphism: APOE polymorphism - HP1/2 common polymorphism
Variant Type: Haplotype
Location: 19q13.2
Factor:
- Symbol: APOE
- Name: apolipoprotein E
- Entrez ID: 348
- Ensembl ID: ENSG00000130203
Factors:
APOE
apolipoprotein E
(
348
/
ENSG00000130203
)
Description:
HP1 allele protects APOE4 carriers. (p=0.013, males)
APOE polymorphism includes haplotype combination of rs429358-rs7412 polymorphisms.
Ethnicity:
Italian
Age of cases: >88
Shorter lived allele: e4-H2 (haplotype)
Finding: Positive
Statistics
- Number of cases/controls: 200 (cases) vs 539 (initial) (initial)
- p-value:
0.013
[0.013 (males)]
- Significant: Yes
Study Design
- Classifications:
No Age Effect
- Study type: Candidate Region/Gene
- Technology: PCR
Reference:
21703254: APOE haplotypes are associated with human longevity in a Central Italy population: evidence for epistasis with HP 1/2 polymorphism.
Choice: Clean
Created: July 2, 2013, 2:33 a.m.
Updated: Aug. 8, 2014, 1:05 p.m.
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