Polymorphism: APOE polymorphism - HP1/2 common polymorphism







Variant Type: Haplotype
Location: 19q13.2

Factor:
- Symbol: APOE
- Name: apolipoprotein E
- Entrez ID: 348
- Ensembl ID: ENSG00000130203

Factors:
  • APOE apolipoprotein E ( 348 / ENSG00000130203 )


  • Description:

    HP1 allele protects APOE4 carriers. (p=0.013, males)

    APOE polymorphism includes haplotype combination of rs429358-rs7412 polymorphisms.

    Ethnicity: Italian
    Age of cases: >88
    Shorter lived allele: e4-H2 (haplotype)
    Finding: Positive

    Statistics
    - Number of cases/controls: 200 (cases) vs 539 (initial) (initial)
    - p-value: 0.013 [0.013 (males)]
    - Significant: Yes

    Study Design
    - Classifications: No Age Effect
    - Study type: Candidate Region/Gene
    - Technology: PCR

    Reference:
    21703254: APOE haplotypes are associated with human longevity in a Central Italy population: evidence for epistasis with HP 1/2 polymorphism.

    Choice: Clean
    Created: July 2, 2013, 2:33 a.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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