Polymorphism: LPA isoform
Variant Type: Haplotype
Location: 6q26
Factor:
- Symbol: LPA
- Name: lipoprotein, Lp(a)
- Entrez ID: 4018
- Ensembl ID: ENSG00000198670
Factors:
LPA
lipoprotein, Lp(a)
(
4018
/
ENSG00000198670
)
Description:
Low molecular weight (LMW) apo a phenotypes (protein isoforms) are associated with a shorter lifespan in men but not in women.
Ethnicity:
Japanese
Age of cases: 80+
Shorter lived allele: Lp(a)F, Lp(a)B
Finding: Positive
Statistics
- Number of cases/controls: 84 (cases) vs 517 (initial)
- p-value:
0.05
[0.05 (men)]
- Significant: Yes
Study Design
- Study type: Candidate Region/Gene
- Technology: SDS-PAGE, immunoblotting (genotype inferred from protein isoforms)
Reference:
11269751: Decreased longevity in Japanese men, associated with low-molecular-weight apolipoprotein(a) phenotypes.
Choice: Clean
Created: June 30, 2013, midnight
Updated: Aug. 8, 2014, 1:05 p.m.
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