Polymorphism: rs1776180
rs1776180
(
SNPedia |
23andMe
)
Variant Type: SNP
Location: 1q42-q43
Factor:
- Symbol: EXO1
- Name: exonuclease 1
- Entrez ID: 9156
- Ensembl ID: ENSG00000174371
Factors:
EXO1
exonuclease 1
(
9156
/
ENSG00000174371
)
Description:
C allele of this promoter SNP (rs1776180) is significantly enriched in female centenarians (German). This finding is replicated in 455 female French centenarians and 109 controls.
Ethnicity:
French,
German
Age of cases: Mean age 101.3
Shorter lived allele: G
Longer lived allele: C
Finding: Positive
Statistics
- Number of cases/controls: 395 vs 411 (initial)
| 455 vs 109 (replication)
- Odds ratio: 1.39
- p-value:
0.01
[<0.01]
- Significant: Yes
Study Design
- Study type: Candidate Region/Gene
- Technology: SNPlexTM Genotyping System and TaqMan1 SNP Genotyping Assays
Reference:
19698732: A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians.
Choice: Curate
Created: June 30, 2013, midnight
Updated: Aug. 8, 2014, 1:05 p.m.
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