Polymorphism: rs11568820-rs4516035-rs10735810-rs1544410-rs17878969
rs11568820-rs4516035-rs10735810-rs1544410-rs17878969
(
SNPedia |
23andMe
)
Variant Type: Haplotype
Location: 12q13.11
Factor:
- Symbol: VDR
- Name: vitamin D (1,25- dihydroxyvitamin D3) receptor
- Entrez ID: 7421
- Ensembl ID: ENSG00000111424
Factors:
VDR
vitamin D (1,25- dihydroxyvitamin D3) receptor
(
7421
/
ENSG00000111424
)
Description:
G-G-C-G-S haplotype was represented significantly more in cases than in controls, again, mosly in males.
Ethnicity:
Caucasian,
Spaniard
Age of cases: >85
Shorter lived allele: G-G-C-G-S
Longer lived allele: non G-G-C-G-S haplotypes
Finding: Positive
Statistics
- Number of cases/controls: 104 vs 114 (initial)
- Odds ratio: 11.5
- p-value:
0.024
[0.024]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: ABI-PRISM 3100 G
Reference:
20407924: Tagging long-lived individuals through vitamin-D receptor (VDR) haplotypes.
Choice: Curate
Created: July 2, 2013, 2:48 a.m.
Updated: Aug. 8, 2014, 1:06 p.m.
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