Polymorphism: rs11568820-rs4516035-rs10735810-rs1544410-rs17878969
rs11568820-rs4516035-rs10735810-rs1544410-rs17878969 ( SNPedia | 23andMe )

Variant Type: Haplotype
Location: 12q13.11

Factor:
- Symbol: VDR
- Name: vitamin D (1,25- dihydroxyvitamin D3) receptor
- Entrez ID: 7421
- Ensembl ID: ENSG00000111424

Factors:
  • VDR vitamin D (1,25- dihydroxyvitamin D3) receptor ( 7421 / ENSG00000111424 )


  • Description:

    G-G-C-G-S haplotype was represented significantly more in cases than in controls, again, mosly in males.

    Ethnicity: Caucasian, Spaniard
    Age of cases: >85
    Shorter lived allele: G-G-C-G-S
    Longer lived allele: non G-G-C-G-S haplotypes
    Finding: Positive

    Statistics
    - Number of cases/controls: 104 vs 114 (initial)
    - Odds ratio: 11.5
    - p-value: 0.024 [0.024]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: ABI-PRISM 3100 G

    Reference:
    20407924: Tagging long-lived individuals through vitamin-D receptor (VDR) haplotypes.

    Choice: Curate
    Created: July 2, 2013, 2:48 a.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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