Sirtuin activators mimic caloric restriction and delay ageing in metazoans.

Authors: Wood JG; Rogina B; Lavu S; Howitz K; Helfand SL; Tatar M; Sinclair D
Year: 2004
Journal: Nature
Abstract: Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a member of the sirtuin family of NAD+-dependent deacetylases. Sirtuin activating compounds (STACs) can promote the survival of human cells and extend the replicative lifespan of yeast. Here we show that resveratrol and other STACs activate sirtuins from Caenorhabditis elegans and Drosophila melanogaster, and extend the lifespan of these animals without reducing fecundity. Lifespan extension is dependent on functional Sir2, and is not observed when nutrients are restricted. Together these data indicate that STACs slow metazoan ageing by mechanisms that may be related to caloric restriction.
Reference

Integration:

Created on Nov. 5, 2012, 5:56 p.m.
Not linked
Integrated: False

No notes
Species: Nematode

Experiments: 0
Interventions:

Resveratrol supplementation

Resveratrol supplementation

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