Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q.

Authors: Larsen PL; Clarke CF
Year: 2002
Journal: Science (New York, N.Y.)
Abstract: The isoprenylated benzoquinone coenzyme Q is a redox-active lipid essential for electron transport in aerobic respiration. Here, we show that withdrawal of coenzyme Q (Q) from the diet of wild-type nematodes extends adult life-span by approximately 60%. The longevity of clk-1, daf-2, daf-12, and daf-16 mutants is also extended by a Q-less diet. These results establish the importance of Q in life-span determination. The findings suggest that Q and the daf-2 pathway intersect at the mitochondria and imply that a concerted production coupled with enhanced scavenging of reactive oxygen species contributes to the substantial life-span extension.
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Created on Nov. 5, 2012, 5:54 p.m.
Not linked
Integrated: False

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Species: Nematode

Experiments: 0
Interventions:

fer-15 mutation

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