The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet.

Authors: Arum O; Bonkowski MS; Rocha JS; Bartke A
Year: 2009
Journal: Aging cell
Abstract: The interaction of longevity-conferring genes with longevity-conferring diets is poorly understood. The growth hormone receptor gene-disrupted (GHR-KO) mouse is long lived; and this longevity is not responsive to 30% caloric restriction, in contrast to wild-type animals from the same strain. To determine whether this may have been limited to a particular level of dietary restriction, we subjected GHR-KO mice to a different dietary restriction regimen, an intermittent fasting diet. The intermittent fasting diet increased the survivorship and improved insulin sensitivity of normal males, but failed to affect either parameter in GHR-KO mice. From the results of two paradigms of dietary restriction, we postulate that GHR-KO mice would be resistant to any manner of dietary restriction; potentially due to their inability to further enhance insulin sensitivity. Insulin sensitivity may be a mechanism and/or a marker of the lifespan extending potential of an intervention.
Reference

Integration:

Created on Nov. 6, 2012, 11:59 a.m.
Not linked
Integrated: False

No notes
Species: House mouse

Experiments: 0
Interventions:

Intermittent fasting

Edit study (Admin) | Add experiment to study (Admin) | Delete study

---

Back to top

---