Cisd2 mediates mitochondrial integrity and life span in mammals.
Authors: Chen YF; Kao CH; Kirby R; Tsai TF Year: 2009 Journal: Autophagy Abstract: CISD2, the causative gene for Wolfram syndrome 2 (WFS2), is a previously uncharacterized novel gene. Using a mouse genetic approach, this work demonstrated for the first time that Cisd2 is involved in mammalian life span control. Cisd2 deficiency in mice leads to mitochondrial breakdown and dysfunction; this is accompanied by cell death with autophagic features and these events precede the two earliest manifestations of nerve and muscle degeneration. Together, they lead to a panel of phenotypic features suggestive of premature aging. This work effectively links Cisd2 gene function, mitochondrial integrity and aging in mammals. Reference
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Created on Nov. 6, 2012, 10:53 a.m. Not linked Integrated: False
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