| alg-1 RNAi | Adult-specific knockdown of the C. elegans argonaute-like gene 1 *alg-1* results in shortened lifespan with a reduction in the mean and maximum lifespan by 9 - 16% and 14%, respectively [21810936]. | Worm | -9.6 to -16.1 | — | -13.7 |
| alg-2 RNAi | RNA interference of alg-2 decreases median lifespan by 24% in wild type animals and 50% in a daf-2 background [18006689]. | Worm | — | -24 | — |
| amt-2 RNAi | RNA interference of amt-2 increases mean lifespan by 20% [17608836]. | Worm | -20 | — | — |
| ant-1.1 RNAi | RNA interference of ant-1.1 increases mean lifespan by 40% [17608836]. | Worm | +40 | — | — |
| aph-2 RNAi | aph-2 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| apr-1 RNAi | apr-1 RNAi in the adulthood extends the lifespan [99999999]. | Worm | — | — | — |
| aps-1 RNAi | aps-1 RNAi in the adulthood extends mean lifespan by 8% without any apparent effect on maximum lifespan [23144747]. | Worm | +7.9 | — | 0 |
| arf-3 RNA | RNA interference of arf-3 does not affect lifespan of wild-type but suppresses lifespan extension by isp-1 mutation [22829775]. | Worm | 0 | — | — |
| arl-8 RNAi | RNA interference of arl-8 decreases median lifespan by 35% in a daf-2 background and 9% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -35 | — |
| arx-4 RNAi | RNA interference of arx-4 decreases median lifespan by 61% in a daf-2 background and 51% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -61 | — |
| asb-1 RNAi | asb-1 RNAi in the adulthood extends the mean lifespan by 7% without changing the maximum lifespan [23144747]. | Worm | +6.4 | — | 0 |
| asg-1 RNAi | RNA interference of asg-1 leads to lifespan extension [15998808]. | Worm | — | — | — |
| asg-2 mutation | Knockout mutations in asg-2 result in developmental arrest and increased lifespan [11410594]. | Worm | — | — | — |
| asm-3 RNAi | RNA interference of asm-3 increases mean lifespan by 50% [17608836]. | Worm | +50 | — | — |
| asp-3 RNAi | RNA interference against asp-3 significantly reduces lifespan of eat-2(ad1116) mutants, without any significant affect on the lifespan of wild-type. Mean and 75%ile lifespan of eat-2 mutants is reduced by 13-14% and 5-9% by asp-3 RNAi [22810224]. | Worm | — | — | — |
| atg-7 RNAi | RNA interference against atg-7 shortens mean lifespan by 23% and maximum lifespan by 30% in a eat-2 mutant background but not in wild-type animals. Thus, atg7 RNAi does not affect lifespan of wild-type, but totally cancels out the lifespan extension effect of eat-2 mutation [17912023]. | Worm | — | — | — |
| atp-2 RNAi | RNA interference of atp-2 results in extended lifespan [12471266]. atp-2 RNAi significantly extends mean lifespan by 14% [11410594]. | Worm | +14 | — | — |
| atp-2 RNAi | Kncokdown of atp-2 via RNAi started after the animal reaches the late L4 stage increase mean lifespan by 12-18% [22103665]. | Worm | +12 to +18 | — | — |
| atp-3 RNAi | RNA interference against atp-3 results in lifespan extension [16103914]. atp-3 RNAi increases lifespan by 46% (mean by 33 and maximum by 70%). RNAi of atp-3 during larval stage is necessary and sufficient for lifespan prologation, while atp-3 RNAi only during the adulthood fails to extend lifespan. atp-3 RNAi results in reduced pharageal pumping, defection and motility as well as ATP levels and body size [12471266]. atp-3 RNAi started after the animal reaches the late L4 stage increases mean lifespan by 7-8% [22103665]. | Worm | +7 to +33 | — | +70 |
| atp-4 RNAi | RNA interference of atp-4 results in lifespan extension [16103914]. | Worm | — | — | — |
| atp-5 RNAi | RNA interference of atp-5 results extended lifespan [16103914]. | Worm | — | — | — |
| B0035.12 RNAi | RNAi of B0035.12 increases mean and maximum lifespan by 12 and 20%, respectively [19293945]. | Worm | +12 | — | +20 |
| B0250.5 RNAi | Knockdown of B0250.5 via RNAi started after the animal reached the late L4 stage increases mean lifespan by 10-14% [22103665]. | Worm | +10 to +14 | — | — |
| B0280.9 RNAi | B0280.9 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| B0303.3 RNAi | Knockdown of B0303.3 via RNAi after the animal reached the late L4 stage has no significant effect on mean lifespan [22103665]. | Worm | — | — | — |
GenAge
GenDR
