| C14A4.14 RNAi | C14A4.14 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| C16C10.2 RNAi | C16C10.2 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| C26B2.2 knockout | C26B2.2 knockout mutations extend lifespan [15253933]. | Worm | — | — | — |
| C47D12.2 RNAi | C47D12.2 RNAi in the adulthood extends mean and maximum lifespan by 6 and 9% [23144747]. | Worm | +5.5 | — | +8.7 |
| C47D12.8 RNAi | C47D12.8 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| C56C10.10 RNAi | C56C10.10 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| cchl-1 RNAi | cchl-1 RNAi extends mean and maximum lifespan by 55% and 57%, respectively. Lifespan extension by RNAi of cchl-1 is not suppressed by daf-16 [12447374].
cchl-1 RNAi animals have lower ATP content and oxygen consumption [12447374]. | Worm | +55 | — | +57 |
| cdc-25.3 knockout | cdc-25.3 knockout mutants also display increased thermotolerance and a 40% lifespan extension [16741121]. | Worm | +40 | — | — |
| cdk-1 RNAi | cdk-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| ceh-6 RNAi | ceh-6 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| cep-1 mutation | cep-1 mutants live up to 33% longer. which is dependent upon functional daf-16 [17895432].
| Worm | +33 | — | — |
| che-2 mutation | che-2 recessive loss-of-function mutations extend lifespan up to 50% (in Bristol N2) [10617200]. che-2 mutants are chemotactic defective, slightly small, defective for osmotic avoidance, have ciliated neurons with abnormal stunted ultrastructure, and are dauer defective [2428682; 1732156]. | Worm | +50 | — | — |
| chn-1 RNAi | chn-1 RNAi in the adulthood extends mean and maximum lifespan by 7 and 9%, respectively [23144747]. | Worm | +7.1 | — | +8.7 |
| ckr-1 RNAi | ckr-1 RNAi significantly reduces lifespan of eat-2 but not that of age-1 nor clk-1 mutants [19783783]. | Worm | — | — | — |
| ckr-2 RNAi | ckr-2 RNAi significantly reduces the lifespan of eat-2 but not that of age-1 nor clk-1 mutants [19783783]. | Worm | — | — | — |
| cnk-1 RNAi | cnk-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| frh-1 RNAi | Complete absence of frataxin is lethal, while its partial deficiency extends animal lifespan in a p53 dependent manner. Frataxin knockdown via RNAi extends mean and maximum lifespan by 19 and 37%, respectively [23247094].
Substantial reduction of frataxin protein expression is required to extend lifespan, affect sensory neurons functionality, remodel lipid metabolism and trigger autophagy. Beclin and p53 genes are required to induce autophagy and concurrently reduce lipid storages and extend animal lifespan in response to frataxin suppression [23247094]. | Worm | +18.75 | — | +37.037037037 |
| csn-5 RNAi | csn-5 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| cup-4 RNAi | cup-4 RNAi reduces oxidative stress resistance and shortens lifespan of wild-type under AL. cup-4 RNAi significantly reduces the extended lifespan of eat-2 mutants, but failed to block lifespan extension of age-1 or clk-1 mutants [19783783]. | Worm | — | — | — |
| cup-5 RNAi | cup-5 RNAi significantly decreases lifespan of eat-2 specifically, whereas lifespan of age-1 or clk-1 mutants are not affected [19783783]. | Worm | — | — | — |
| cyd-1 RNAi | cyd-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| cye-1 RNAi | cye-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| cyn-7 RNAi | cyn-7 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| daf-1 mutation | daf-1(mk40) mutation increases mean lifespan by 18-46% and maximum lifespan by 29% [17900898]. The daf-1(m40) allele has no effect on lifespan and fails to prevent lifespan extension by sir-2.1 overexpression, but it results in a temperautre-sensitive, dauer-constitutive phenotype in larvae [11242085]. | Worm | +18 to +46 | — | +29 |
| daf-14 mutation | daf-14(m77) mutation increases mean lifespan by 21-44% and maximum lifespan by 29% [17900898]. | Worm | +21 to +44 | — | +29 |
GenAge
GenDR
