Denigma

Interventions

  • Species: + -
    House mouse « 
  • Manipulation: + -
    Mutation «  Gain‑of‑Function «  Loss‑of‑Function (1)   Overexpression (1)   Deletion (1)   Replacement (1)  
    • name effect species mean median maximum
    Heterozyogus Trp53 truncation mutation Mice heterozyogous for an allele of p53 that removes the 5' portion of the protein demonstrate decreased cancer, permature aging phenotypes, and shortened lifespan in the mixed inbred C57BL/6–129/Sv background. It has been proposed that the this allele of p53 results in increased activity/overexpression [11780111]. Mouse — — —
    Replacement of Cebpa by Cebpb Replacing the Cebpa gene by Cebpb increases mean lifespan by about 20% [15289464]. C/ebpalpha(beta/beta) animals consume more food but weight less than controls [10982846], and have a slightly elevated body temperature (0.3-0.5 degree Celsius) [15289464]. Mouse +20 — —
    • 2 interventions
    Interventions are an extension of GenAge and GenDR.