Denigma: Interventions

Interventions

Budding yeast «

Loss‑of‑Function « Overexpression « Mutation (1)

name	effect	species	mean	median	maximum
Overexpression of truncated TLC1	Overexpression of a truncated allele of TLC1 abrogates telomere silencing [7545955], shortened telomeres and extends replicative lifespan approximately by 20% [9275199]. Deletion of TLC1 might decrease replicative lifespan [Nugent et al., 1996].	Yeast	+20	—	—

Interventions are an extension of

GenDR.