| Buffering pH to 6.0 | Buffering the pH to 6.0 extends chronological lifespan [21076178]. | Yeast | — | — | — |
| GSH Treatment | GSH treatment increases chronological lifespan [21076178]. | Yeast | — | — | — |
| CTA1 Deletion | Deletion of CTA1 increases chronological lifespan [21076178]. | Yeast | — | — | — |
| PDE2 Deletion | Deletion of PDE2 decreases mean replicative lifespan by 26% [11000115] and also results in a shorter chronological lifespan [21076178].
PDE2 null mutant are sensitive to oxidative stress [10394911]. | Yeast | -26 | — | — |
| SNF1 deletion | Deletion of SNF1 increases replicative lifespan by 50% in the alpha strain [19030232], but decreases chronological lifespan [21076178]. | Yeast | +50 | — | — |
| RIM15 deletion | RIM15 deletion results in 50% reduction of maximal chronological lifespan [11292860] and consistently decreases chronological lifespan under AL [21076178]. Rim15 is required for chronological lifespan extension caused by deficiency in RAS2, TOR1, or SCH9, as well as by 0.5% glucose restriction, but not by water starvation [18225956]. | Yeast | — | — | — |
| SIC1 Deletion | SIC1 deletion decreases chronological lifespan [21076178]. | Yeast | — | — | — |
| SOD2 deletion | SOD2 deletion decreases replicative lifespan by 72% [17460215]. SOD2 deletion decreases chronological lifespan [21076178]. Deletion of SOD2 decreases chronological lifespan in wild-type and abolishes chronological lifespan extension in sch9Delta mutants as well as decreases chronological lifespan in cyr1:mTn mutants [12586694].
SOD2 deletion mutants are hypersensitive to oxygen and grow poorly in ethanol [10222047]. | Yeast | -72 | — | — |
| High Glucose | High glucose concentration decreases chronological lifespan [21076178]. | Yeast | — | — | — |
| N-acetylcysteine Treatment | Treatment with N-acetylcysteine decreases chronological lifespan [21076178]. | Yeast | — | — | — |
| ATP2 Deletion | ATP2 deletion decreases replicative lifespan by 50% in the alpha strain [18340043]. | Yeast | — | — | — |
| HXK2 deletion | Deletion of HXK2 extends mean and maximum replicative lifespan by about 53% and 33%, respectively. Limiting glucose availability by mutating HXK2 significantly extends replicative lifespan and provides a genetically model of DR [11000115]. HXK2 deletion increases oxygene consumption. Changes in gene expression HXK2 mutation are quite similar to those of dietary-restricted cells. In fact, HXK2 mutants have a transcriptional profile that significantly resembles DR cells and cell overexpressing HAP4 [12124627]. | Yeast | +53 | — | +33 |
| VPS21 deletion | Lack of VPS21 reduces lifespan under starvation conditions to a level similiar to that of wild-type cells incubated in synthetic complete medium and therefore blocked the lifespan-extending effect of DR [20657825]. | Yeast | — | — | — |
| ATG7 deletion | ATG7 deletion reduces chronological lifespan by 70% [19302372]. | Yeast | — | — | — |
| VPS8 deletion | Lack of VPS8 reduces lifespan under starvation conditions to a level similiar to that of wild-type cells incubated in synthetic complete medium and therefore blocked the lifespan-extending effect of DR [20657825]. | Yeast | — | — | — |
| VPS25 deletion | Under starvation conditions VPS25 deletion mutants have a dramatically reduced lifespan [20953148]. | Yeast | — | — | — |
| VPS27 deletion | Under starvation conditions VPS27 deletion mutants have a dramatically reduced lifespan [20953148]. | Yeast | — | — | — |
| SAM1 deletion | Deletion of SAM1 increases replicative lifespan by 20% in the alpha strain and 15% in the a strain [18340043]. | Yeast | +15 to +20 | — | — |
| OSH6 overexpression | Elevation of OSH6 levels by an ERG6 promoter extends mean, median and maximum replicative lifespan by 39, 52 and 18% which is non-additive with 0.5% glucose restriction. It also extends the lifespan of NYV1 mutant [Geber et al., unpublished].
The long lifespan of Perg6-OSH6 is not further extended by deletion of TOR1 [22622083].
OSH6 overexpression decreases total cellular sterol content and reduces Lst8 protein levels. The CC domain of Osh6 is dispensable for longevity [Fusheng Tang, personal communication]. | Yeast | +39 | +52 | +18 |
| HES1 overexpression | Elevation of HES1 levels by an ERG6 promoter reduces mean, median and maximum replicative lifespan by 25, 18 and 29% [Geber et al., unpublished] | Yeast | -25 | -18 | -29 |
| HES1 deletion | Deletion of HES1 (alias OSH5) extends mean replicative lifespan by 27% and is non-addative with moderate DR. Deletion of OSH5 delays different steps of endocytosis, a sterol-requireing process. [Xia et al., unpublished]. | Yeast | — | — | — |
| INP53 deletion | Deletion of INP53 increases mean replicative lifespan by 31% [16293764]. INP53 deletion increases replicative lifespan by 31% in the alpha strain and by 10% in the a strain [18340043]. | Yeast | +31 | — | — |
| ATG18 deletion | The replicative lifespan of ATG18 deletion mutant is not shorter than that of wild-type under DR [18690010]. | Yeast | — | — | — |
| CKA2 deletion | CKA2 deletion approximately doubles mean chronological lifespan under starvation/extreme DR in BY4741 also increases as well as as heat-shock resistance in SDC medium in the W303-1A and DBY746 genetic backgrounds [20657825]. | Yeast | — | — | — |
| CKB2 deletion | Lack of Ckb2 promotes a modest but significant chronological lifespan extension and marked increase in yeat resistance [20657825]. | Yeast | — | — | — |
GenAge
GenDR
