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Denigma
»
Lifespan
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Interventions
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Mouse Lifespan Experiments
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Interventions
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Species:
+
-
Budding yeast (3)
Manipulation:
+
-
Loss‑of‑Function «
Knockdown «
Mutation «
Deletion «
name
effect
species
mean
median
maximum
SOD2 deletion
SOD2 deletion decreases replicative lifespan by 72% [
17460215
]. SOD2 deletion decreases chronological lifespan [
21076178
]. Deletion of SOD2 decreases chronological lifespan in wild-type and abolishes chronological lifespan extension in sch9Delta mutants as well as decreases chronological lifespan in cyr1:mTn mutants [
12586694
]. SOD2 deletion mutants are hypersensitive to oxygen and grow poorly in ethanol [
10222047
].
Yeast
-72
—
—
FKH1 FKH2 deletion
Deletion of FKH1 or FKH2 has no effect on neither replicative, nor chronological lifespan [
18225956
]. Deletion of both FKH1 and FKH2 reduces mean chronological lifespan by 50% and abrogates lifespan extension and increased stress resistance conferred from water starvation (extreme DR). Modest increase in FKH1 or FKH2 expression results in a slight increased chronological and replicative lifespan as well as stress resistance [
22438832
].
Yeast
—
—
—
GIS1 deletion
Deletion of GIS1 increases replicative lifespan by 25% in the alpha strain [
19030232
] and causes major although not complete reversion of chronological lifespan extension by 0.5% glucose restriction [
18225956
].
Yeast
—
—
—
3 interventions
Interventions are an extension of
GenAge
and
GenDR
.