| daf-1 mutation | daf-1(mk40) mutation increases mean lifespan by 18-46% and maximum lifespan by 29% [17900898]. The daf-1(m40) allele has no effect on lifespan and fails to prevent lifespan extension by sir-2.1 overexpression, but it results in a temperautre-sensitive, dauer-constitutive phenotype in larvae [11242085]. | Worm | +18 to +46 | — | +29 |
| daf-10 mutation | Loss of function mutation in daf-10 increases lifespan by 60% (in Bristol N2) [10617200]. daf-10 mutants are dauer defective, dye filling defective, octopamine deficient and have abnormal chemotaxis and osmotic avoidance. Mutants in daf-10 display abnormal sensory anatomy, especially amophidial neurons and sheath cells, and cephalic neurons. daf-10 mutant males do not mate [2428682]. | Worm | +60 | — | — |
| daf-12 mutation | Mutations in daf-2 and daf-12, but not mutations in daf-12 alone, nearly quadruples lifespan [7789761]. Recessive loss of function mutation in daf-12 shortens lifespan. daf-12 activity is required for lifespan extension after germ line ablation [10360574]. daf-12 mutation suppresses the lifespan extension by mutation in daf-28 [8807293]. daf-12 mutants are dauer defective and heterochronic [7219552]. Some daf-12 alleles exhibit synthetic lethality with mutation of age-1 [8807293] or daf-12 [1732156]. | Worm | — | — | — |
| daf-15 mutation | Mutations in daf-15 (raptor) extends adult lifespan by 15-30% in a daf-16 dependent manner. daf-15 mutation are dauer defective [15253933]. | Worm | +15 to +30 | — | — |
| hsb-1 mutation | hsb-1(cg116) mutation at 20 degree Celsius extends mean, 75%ile, and maximum lifespan by 57-60%, 52-59%, and 37-69%.
| Worm | +57 to +60 | — | +37 to +69 |
| daf-18 mutation | daf-18 is required for complete dauer formation. daf-18 mutation partially suppresses the lifespan extension of age-1 and daf-2 mutants. daf-18 mutants are defective for dauer formation and form some dauer-like larvae when starved [7789761; 8601482]. | Worm | — | — | — |
| daf-19 mutation | Loss-of-function mutations in daf-19 increase lifespan up to 50% [10617200]. daf-19 mutants are dauer constitutive, dye-filling defective, and lack sensory cilia [7219552; 9475731]. | Worm | +50 | — | — |
| daf-4 mutation | daf-4(e1374) mutation increases mean and maximum lifespan by 40-120% and 76-83%. daf-4(m63) allele has no effect on lifespan and fails to prevent lifespan extension by sir-2.1 [11242085]. mutation of daf-4 results in a temperature-sensitive, dauer-constitutive phenotype in larvae. sir-2.1 overexpression in the daf-4(m63) background results in an increase in the severity of the dauer-constitutive phenotype [11242085]. | Worm | +40 to +120 | — | +76 to +83 |
| daf-6 mutation | Loss-of-function mutations in daf-6 extend lifespan by up to 50% [10617200]. daf-6 mutants are dauer defective, chemotaxis defective, osmotic aviodance (osm), male mate poorly, and, dye filling defective [2428682]. Mutants of daf-6 have defective sheath cells causing the amphid and phasmids pores to be closed. | Worm | +50 | — | — |
| daf-9 mutation | Mutations in daf-9 increase lifespan up to 52% [11740945]. Mutation of daf-9 extends mean and maximum lifespan at 15 degree Celsius by 15-75% and 28-96%, respectively [11782415]. Lifespan extension conferred by mutation of daf-9 is suppressed by mutation of daf-12, but not by mutation of daf-16. daf-3 mutation results in a wild-type lfiespan, but greatly extends the long-lived daf-9 mutant lifespan. daf-9 mutants are dauer-constitutive [3350212], exhibit gonadal cell migration defect [11782415], and a post-dauer molting defect. | Worm | +15 to +75 | — | +28 to +96 |
| daz-1 mutation | Mutation of daz-1 has no effect on lifespan [11799246]. daz-1 mutants are sterile and have a gonad that contains small nuclei and no oocytes [10662646]. Although sperm production is normal, oocytes precursors arrest at meiotic prophase and undergo apoptosis | Worm | — | — | — |
| eat-10 mutation | The eat-10(ad606) allele exhibits no significant extension of lifespan [9789046], but displays defects in pharyngeal feeding behaviour [8462849]. | Worm | — | — | — |
| eat-18 mutation | Mutations in eat-18 extend lifespan by 15-60%. Lifespan extension is proposed to be similar to DR [9789046]. eat-1 mutants have defects in pharyngeal feeding behavior [8462849]. | Worm | +15 to +60 | — | — |
| eat-13 mutation | The eat-13(ad522) allele extends lifespan by 30%. Extension of lifespan is proposed to be similar to DR [9789046]. eat-1 mutants have defects in pharyngeal feeding behavior [8462849]. | Worm | +30 | — | — |
| eat-3 mutation | The eat-3(ad426) allele extends lifespan by 10%. Lifespan extension is proposed to be similar to DR [9789046]. eat-1 mutants have defects in haryngeal feeding behavior [8462849]. | Worm | +10 | — | — |
| eat-5 mutation | The eat-5(ad464) allele has no significant effect on lifespan [9789046], although it displays defects in pharyngeal feeding behaviour [8462849]. | Worm | — | — | — |
| eat-6 mutation | Mutations in eat-6 extend lifespan by 15-40%. Lifespan extension is proposed to be similiar to DR [9789046]. eat-1 mutants have defects in haryngeal feeding behavior [8462849]. | Worm | +15 to +40 | — | — |
| eat-7 mutation | The eat-7(ad450) allele decreases lifespan by 35% [9789046] exhibits defects in pharyngeal feeding behavior [8462849]. | Worm | -35 | — | — |
| egl-4 mutation | Mutations in egl-4 extends lifespan by up to 55%. Lifespan extension by mutation of egl-4 is suppressed by daf-16. egl-4 mutation results in normal morphology and development, however egl-4 animals are almost twice as big as normal and have weak eff-laying defects [12571101]. | Worm | +55 | — | — |
| fem-3 mutation | fem-3(e1996) mutants do not produce sperm or self-progeny, therefore develop as females, but have a normal lifespan (See also ref 10) [8247153]. | Worm | — | — | — |
| fer-15 mutation | Mutation of fer-15 results in a slight (10%) reduction in mean lifespan. Dietary restriction of coenzyme Q extends the lifespan of fer-15 animals. fer-15(b26ts) animals are temperature sensitive and sterile [11778046]. | Worm | -10 | — | — |
| fog-1 mutation | The fog-1(q180) allele has no effect on lifespan [11799246]. fog-1 mutants are sterile and make oocytes but not sperm [2341035]. | Worm | — | — | — |
| fog-2 mutation | fog-2(q71) allele has no effect on lifespan [10747056]. fog-2 mutant display hermaphrodite specific germ line feminization [11076749]. | Worm | — | — | — |
| gro-1 mutation | Mutation in gro-1 extends lifespan extension by 29% and slows growth. Post-embryonic growth rate is greatly reduced in gro-1 mutants. gro-1 mutant exhibit increased resistance to heat-shock and tends to avoid bacterial lawn [Mutation in gro-1 extends lifespan extension by 29% and slows growth. Post-embryonic growth rate is greatly reduced in gro-1 mutants. gro-1 mutant exhibit increased resistance to heat-shock and tends to avoid bacterial lawn [8638122]. | Worm | +29 | — | — |
| isp-1 mutation | A missense mutation in isp-1 leads to low oxygen consumption, decreased sensitivity to reactive oxygen species, and increased mean (60%) and maximum (100%) lifespan. An isp-1;daf-2 double mutant has a lifespan that is longer than either single mutant, but the lifespan extension of the double mutant is not addative relative to each single mutant [11709184]. | Worm | +60 | — | +100 |
GenAge
GenDR
